一、前言 - 暨南大学.pdf

053310401020070618221233.doc 1-2 (fibroblast growth factors,FGFs) [1] 25 , -2(keratinocyte growth factor-2,KGF-2) -10(FGF-10)FGFs(keratinocyte growth factors, KGFs)KGFsKGF-1KGF-2 [2] 1989Rubin 26-28KD (KGF)1996Yamasaki[3] -10(FGF-10) KGF 53%, KGF-2 FGFs KGFsFGFR2-b [4] 1.1 KGF-2 KGF-2, TKGF-2 KGF-2 [5] KGF-25p12-p13 [6] [7] 32 1997Emoto KGF-2 cDNA208N39 16954 219.3KD KGF-2 FGF [2] - 053310401020070618221233.doc 1.2 KGF-2 FGFs (fibroblast growth factor receptors , FGFRs) FGFRs 3 (110150)10 , (1)(23) (2) (3)FGFRs4FGFR1 FGFR2 FGFR3 FGFR4 4flgbek fgfr3 flg-2 FGFRs [8] FGFR1 FGFR2FGFR3 KGF-2FGFR1-b FGFR2-b KGF-2FGFR2 FGFR2-b FGFR1FGFR1-b[9, 10] KGF-2FGFR2- b KGF-2C [11, 12] [13] Brian KGF2-FCFR2IIIbKGF2-FCFR2IIIb KGF-2β-12β-(β1β12) β-FGFs KGF-2 N a-D3D2D3 FCFR2IIIb D2D3β- 053310401020070618221233.doc .1 FGF10-FGFR2b Fig. 1. Overall structure of the FGF10-FGFR2b complex. (a) Ribbon diagram of the FGF10-FGFR2b complex. D2 of FGFR2b is colored green. The first half of D3 is shown in blue. The alternatively spliced second half of D3 is colored purple. The linker connecting D2 and D3 is colored gray. FGF10 is shown in orange. The β-strands of FGF10 and FGFR2b are labeled accord