多通道spr 影像传感器及其对dna 的特异性检测 - 电子学报.pdf

11 Vol. 34 No. 11 2006 11 ACTA ELECTRONICA SINICA Nov. 2006 SPR DNA 刘国华, 张福海, 俞 梅, 贾芸芳, 张 维, 岳 钊, 常 露, 牛文成 ( , 300071) : SPR , ( ) , ( ) . SPR . , SPR , , , . DNA , . : ; ; ; DNA : TP2123 : A : (2006) MultiChannel SPR Imaging Sensor and Specific Detection of DNA LIU Guohua, ZHANG uhai, YU Mei,JIA Yunfang, ZHANG Wei,YUE Zhao, CHANG Lu, NIU Wencheng ( College of I nf ormation Technol ogy , N ankai Univers ity , Tianj in 300071, Chi na ) Abstract: The response of SPR sensor includes two components:specific response and nonspecific response.The former is due to the capture of analyte molecules by target molecules immobilized on the sensor surface, and the latter is due to the adsorption of nontarget molecules to sensor surface and temperature fluctuations or sample variations of composition and concentration. The existence of nonspecific response reducesthe precision of SPR sensors.In this paper we provide a kind of multi channel SPR imag ing sensor structure to improve the accuracy of SPR sensors.It can discriminate between the specific response and the nonspecific response by comparison of different channels, and realize the realtime detection of the biomolecular interactions. This method is demonstrated effective on specific detection by testing for DNA. Key words: surface plasmon resonance; multichannel imaging sensor; specific response; DNA(deoxyribonucleic acid) . 1 , , 1983 ( Surface Plasmon Resonance, ,