双氯芬酸钠药物树脂复合物的体外释放特性.pdfVIP

蔓!虫!竺!!!竺堂!!盟!!旦型g!!塑!：!!!：!!盟!：! 双氯芬酸钠药物树脂复合物的体外释放特性 吴静，王超，李宁，刘宏飞，周丽莹，潘卫三 10016) (沈阳药科大学药学院，沈阳1 【摘要] 目的：制备双氯芬酸钠药物树脂复合物，对其体外释药动力学进行考察。方法：采用不同交联 度的离子交换树脂以静态法制备双氯芬酸钠药物树脂复合物并对双氯芬酸钠药物树脂复合物释放的影响因 素进行考察。结果：随着树脂交联度的减小，树脂对双氯芬酸钠的载药速率变快，载药量增加。体外释药动 力学研究表明，双氯芬酸钠药物树脂的释药速率随着温度的升高和溶出介质中离子强度的增大而加快；而且 与树脂本身性质也有关，释药速率随着树脂交联度和粒径的减小而增大；双氯芬酸钠药物树脂的释放为pH 依赖型。结论：双氯芬酸钠药物树脂的释药速率与释放温度、溶出介质的离子强度和pH值及树脂交联度和 粒径有关。 [关键词]双氯芬酸钠；离子交换树脂；离子交换反应；释药动力学 [中图分类号】R943．4；R971．1 Releasekineticsofdiclofenacsodium invitro drug-resincomplexes WU Chao，LI Wei—san Jing，WANG Ning，LIUHong—fei，ZHOULi—ying，PAN Pharmaceutical 110016，China) (SchoolofPharmacy，ShenyangUniversity，Shenyang thediclofenacsodium and thereleasekinetics [Abstract]0bjective：Toprepare drug—resincomplexesstudy ofthe invitro．Methods：The weremadewithvariouscross—linkedion complexes drug-resincomplexes drug-resin diclofenacsodiumreleasefrom resinbatchmethod．Thefactorsthatinfluenced drug—resincomplexes exchangeby ofthecross werealso rateandamountsof wereincreasedwiththereduction investigated．Results：Theloadingdrug ofresin．Thereleasekineticsinvitroshowsthatthereleaseratewasincreasedwiththeincreaseoftempera— linkage tureandionic oftherelease well decreaseofcross and sizeoftheres— strength mediums，asas，the linkageparticle thereleasebehaviorofdielofenacsodiumresinshoweda in．And drug pHdependent releaserateofdiclofenacsodium wascorrelatedw