健脾化浊方治疗脾虚痰湿型非酒精性脂肪肝疗效观察及机制探讨.pdfVIP

提 要 目的：通过临床观察，研究健脾化浊方治疗非酒精性脂肪性肝病（NAFLD ）脾 虚痰湿证的临床疗效和不良反应，客观地评价其治疗 NAFLD 的有效性及安全性。 方法：以符合标准的 60 例NAFLD 患者为研究对象，随机分为中药组（健脾化 浊方）和对照组（水林佳）各 30 例，比较两组患者治疗前后的临床证候、血清肝酶 (ALT、AST、γ-GT)、血脂(TC、TG)、血糖、胰岛素抵抗和肝脏B超等的改善情况。 结果：经统计学分析，与治疗前相比，治疗后两组患者临床指标均有不同程度的 改善（P0.05 或 P0.01 ）。两组间比较，除血清肝酶指标改善无统计学意义之外 （P0.05 ），余各指标改善情况中药组均不同程度优于对照组，经比较具有统计学意 义（P0.05 或 P0.01 ）。 结论：健脾化浊方使 NAFLD 脾虚痰湿证患者临床症状得到缓解，保肝降酶、调 脂降糖，同时肝脏 B 超影像学也得到改善，可作为安全有效的方剂指导临床治疗。 关键词 健脾化浊方；非酒精性脂肪性肝病；脾虚痰湿证 Clinical Observation and mechanism of the Treatment Spleen Weakness Phlegm Wet Card of Nonalcoholic Fatty Liver Disease with Jianpihuazhuo Decoction Speciality: Clinical Study of Integrated TCM and Western Medicine Author:Wang qiong Tutor: Sun Jianguang Abstract Objective: To observe the clinical effect and adverse reactions of Jianpihuazhuo Decoction treatment of Spleen weakness Phlegm wet card of Nonalcoholic fatty liver disease (NAFLD), to valuate objectively its effectiveness and safety of the treatment of NAFLD. Methods: Selected met the inclusion criteria 60 cases of outpatients, Were randomly divided into traditional Chinese medicine (TCM) group (Jianpihuazhuo Decoction) and the control group (Shui Linjia) 30 patients in each Therapy of 12 weeks in both groups compared in patients with TCM score, serum markers (ALT, AST, γ-GT) , （TC, TG ）, FBG, IRI and Liver B-imaging improve the situation.. Results: The statistical analysis of test data, compared with those before treatment and after treatment, the observation of two groups of indicators have different levels of statistical significance (P0.05 or P0.01). To improve the