化瘀消疕饮合走罐法治疗斑块型银屑病的临床研究和对TNF-α、IL-8的影响.pdfVIP

提 要 目的：观察化瘀消疕饮联合走罐疗法治疗斑块型银屑病的临床疗效，并观察对 TNF-α、IL-8水平的影响。方法：将60例斑块型银屑病患者随机分为两组，试验组 口服化瘀消疕饮外用卡泊三醇加走罐，对照组口服消银片、复方丹参片外用卡泊三 醇，疗程3个月。观察两组患者治疗前后红斑、鳞屑、浸润程度、瘙痒、皮损面积、 全身症状变化及不良反应发生情况。用放射免疫-饱和液相竞争法测定两组患者治 疗前后血清TNF-α、IL-8变化。结果：总有效率试验组93.33%，对照组76.67%，试 验组与对照组对比有明显差异（P＜0.05），试验组疗效优于对照组。治疗后两组患 者血清TNF-α、IL-8水平均较治疗前下降，治疗前后两组组内比较差异有统计学意 义（P＜0.05），治疗后两组组间比较差异有统计学意义（P＜0.05），试验组优于对 照组。结论：化瘀消疕饮治疗银屑病疗效确切，副作用少，其作用机制可能是通过 活血化瘀，改善微循环，调节细胞因子水平而发挥治疗作用。联合走罐法，可通过 罐法的负压、温热等作用，达到疏通经络、行气活血的作用，从而加速斑块变薄， 促进皮损消退，提高疗效，缩短疗程。 关键词 斑块型银屑病；走罐疗法；临床研究；TNF-α；IL-8 HuaYuxiaobi decoction taken orally with the cutem and Calcipotriol in Treating plaque Psoriasis Vulgaris and Detection of TNF-α and IL-8 Speciality： Dermatology ，Surgery of TCM Auther ： Wan Shanshan Tuter： Professor Geng Lidong Abstract Objective：To observe the clinical efficacy of HuaYuxiaobi decoction combined with cutem and the external use of Calcipotriol in treatment of plaque psoriasis vulgaris and to investigate the possible mechanisms and the function of TNF-α and IL-8 in the pathogenesis of PV. Methods ：30 patients with plaque psoriasis vulgaris had received the HY combined with cutem and the external use of Calcipotriol for 12 weeks，compared with the other 30 received XiaoYin tablets and FuFangdanshen tablets and the external use of Calcipotriol. Measure the level of serum TNF-α and IL-8 before and after the treatment. Results ：The clinical cure and obvious rate was 70.00%，the effective rate was 93.33% ， the control group were 40.00% and 76.67%. As to the recrudescent rate and the side-effective rate，there were significant differences between the two groups. The level of serum TNF-α and IL-8 decreased obviously after the treatment. Conclusions