化瘀止痛胶囊合敷脐止痛散配合治疗子宫腺肌病的临床探究.pdfVIP

提 要 目的：观察化瘀止痛胶囊配合敷脐止痛散综合治疗子宫腺肌病的临床疗效并探讨 其作用机理。方法：临床选取65例子宫腺肌病患者，其中治疗组35例，经前及经期 外用敷脐止痛散，经期服用化瘀止痛胶囊；对照组 30 例，经前及经期外用花季（神 阙贴），经期服用散结镇痛胶囊。观察两组患者痛经、月经及临床症状的改善，子宫 体积大小、血清CA125、PGE2 、肿瘤坏死因子-α（TNF-α）的变化。结果：治疗后治 疗组患者总疗效、中医证候疗效、月经不调疗效、中医单项症状积分与对照组组间比 较均有显著性差异（P0.05），治疗组优于对照组。治疗后两组患者痛经积分及血清 PGE2 含量下降，较疗前均有显著性差异（P0.05）；组间比较无差异（P＞0.05）。治 疗组子宫体积、血清 CA125、肿瘤坏死因子-α含量较疗前降低有显著性或非常显著 性差异（P＜0.05 或 P＜0.01），对照组与疗前比较无差异（P＞0.05）；治疗后组间 比较有显著性差异或者非常显著性差异（P＜0.05或 P＜0.01），治疗组优于对照组。 结论：化瘀止痛胶囊配合敷脐止痛散综合治疗子宫腺肌病疗效较好，既可缓解痛经症 状，又可调理月经的紊乱，其改善月经方面的作用与对照组比较尤为显著；其治疗作 用可能是通过抑制异位内膜的侵袭力，抑制子宫内膜及肌层内新生血管的生长从而减 少内膜的增生种植、缩小异位病灶进而缩小子宫体积，减少月经量有关。 关键词 子宫腺肌病；化瘀止痛胶囊；敷脐止痛散；肿瘤坏死因子-α The Clinical Research on the Effect of HuaYuZhiTong Capsule and FuQiZhiTong Powder in Treating Adenomyosis Speciality: Gynecology of TCM, The study of menstruation sickness and sterility Tutor: Professor Ye Qing Author: Zhang Jing Abstract Objective： Observe the clinical curative effect of HuaYuZhiTong Capsule combined with FuQiZhiTong Powder, which is applied to treat adenomyosis dysmenorrhea and explore its work mechanism. Methods: We totally observed 65 patients of adenomyosis and it was divided into two groups randomly. The treatment group take HuaYuZhiTong Capsule combined with FuQiZhiTong Powder, while the control group takes SanJie ZhenTong capsule and HuaJi, which are compared to observe their curative effects and impacts on CA125 、prostaglandin E2 and tumor necrosis factor - α. Results: After treatment, the dysmenorrhea level score of the two groups were obviously decreased (P0.05) but there were no significant differences between groups (P ＞0.05). The syndrome score of the trea