化瘀通络法治疗冠心病稳定型心绞痛（心血瘀阻证）的临床探究.pdfVIP

提 要 目的：观察通络汤治疗稳定型心绞痛心血瘀阻证的临床疗效，并初步探讨其作用 机制。方法：随机选择稳定型心绞痛心血瘀阻证患者50例，分为治疗组（26例）和 对照组（24例）。分别予以通络汤和复方丹参滴丸对照治疗，4周后观察疗效。结果： 心绞痛总有效率治疗组、对照组分别为 73.1%和 70.8%，治疗组与对照组疗效接近 （P0.05）；中医证候疗效治疗组总有效率为96.2%、对照组为83.3%，治疗组优于对 照组（P0.05）；心电图疗效，治疗组总有效率为46.15%、对照组为41.67%，治疗组 与对照组疗效接近（P0.05）。结论：通络汤是临床上治疗心绞痛心血瘀阻证的一个 安全、疗效确切的中药方剂，能明显缓解胸闷、胸痛、气短、乏力等临床症状，有效 改善心电图，降低硝酸甘油用量，其作用机理可能与改善心肌缺血、抗凝、降低心肌 耗氧量、改善动脉粥样硬化的危险因素等有关。本试验提示：活血祛瘀通脉是治疗冠 心病心绞痛心血瘀阻证的常用有效方法。 关键词 冠心病心绞痛；通络汤；临床研究；中医药治疗 Clinical Research on Coronary Heart Disease Angina Treated with Tong Luo Decoction Speciality: Internal Medicine of Traditional Chinese Medicine Author:Cui JingXia Tutor: Pro. Wang Cuiping Abstract Objective:To observe the clinical effect of Tong Luo Decoction on the disease of coronary heart disease (CHD) agina and to probe its mechanism of action . Methods: 50 patients of CHD with stable tired agina of grade Ⅰ～Ⅲwere chosen ,and divided randomly into experiment group(n=26) and control group(n=24).The experiment group was treated with Tong Luo Decoction,while the control group was treated with Fu fang dan shen Capsule.Four weeks later ,we observed the effect on the patients. Result : Respectively, the totle effective rate of the experiment group is 73.1% and the control group is 70.8 %;the effects are mostly the same(P0.05); the totle effective rate of the symptoms on traditional Chinese medicine is96.2% ,83.3 %;ECG total effective rate is 46.15 % ,41.67%;the effects of the two groups are mostly the same(P0.05). Conclusion:It is pointed that Tong Luo Decoction is effective and safe for the patients with CHD.It has huoxuequyu and tongluo analgesic efficacy. It can relief the clinical symptoms effectually, improve the ECG ,reduce the amm