化瘀通脉方治疗慢性脑供血不足痰瘀互阻证的临床探究.pdfVIP

提 要 目的：观察化瘀通脉方治疗慢性脑供血不足痰瘀互阻证的临床疗效,并探求其可 能的作用机理。 方法：临床研究选择符合临床纳入标准的病例 60 例，采用随机方法分为化瘀通 脉组30例，脑心通组30例，4周为一个疗程，共两个疗程。观察两组治疗方法对慢 性脑供血不足患者痰瘀互阻证证候积分的影响，并进行脂蛋白a、超敏C反应蛋白、 血尿酸含量的检测。 结果：临床研究表明，化瘀通脉方能明显改善慢性脑供血不足痰瘀互阻证患者的 临床症状，并能有效降低其脂蛋白a、超敏C反应蛋白及血尿酸水平。两组在治疗剂 量下均未出现严重不良反应。 结论：1.化瘀通脉方对慢性脑供血不足痰瘀互阻证具有较好的治疗效果。2.化瘀 通脉方治疗慢性脑供血不足的作用机理可能与其能够有效调节脂质代谢、减轻炎性反 应、降低尿酸水平等有关。 关键词 化瘀通脉方；慢性脑供血不足；临床研究 Clinical study of Huayutongmai Decoction in treating phlegm and blood stasis syndrome of CCCI Speciality: Internal Medicine Department of Traditional Chinese Medicine Author: Zhang Hongling Tutor: Prof. Li Changsheng Abstract Objective: To study the clinical effect and the possible action mechanism of Huayutongmai decoction in treating CCCI. Methods ：60 cases with CCCI were selected and randomly divided into 2 groups, 30 cases of Huayutongmai decoction treating group and 30 cases of Naoxintong capsule control group. The results were assessed mainly by several indexes including the change of Lp(a) level, Hs- CRP level, BUA level and the syndrome integral changes of patients with phlegm and blood stasis syndrome of CCCI. Results: Clinical studies showed that Huayutongmai decoction can obviously improve symptoms in patients with CCCI, and degrade the level of Lp(a), Hs- CRP and BUA effectually. Conclusion： 1. Huayutongmai decoction is obviously effective on treatment of CCCI; 2. The possible action mechanism of Huayutongmai decoction in treating CCCI may be related to the mechanism that it can be effective in regulating lipid metabolism, reducing inflammatory reaction and reducing the level of BUA. Key words Huayutongmai decoction; CCCI; clinical study