十二味地黄汤对高血压患者早期肾损害的临床干预探究.pdfVIP

提 要 目的：观察十二味地黄汤对高血压患者早期肾损害的临床干预研究。 方法：根据纳入病例标准，选取 60 例高血压伴早期肾损害患者，随机分为治疗 组和对照组。对照组30例，给予常规西药治疗；治疗组30例，在常规西药治疗基础 上加服十二味地黄汤，一日一剂，二次分服，8周后进行临床疗效评定。分别于治疗 前、后行血压测量，尿微量蛋白，肾功能等实验室检查，观察患者血压、症状、体征 及肾功能水平在治疗前后的变化，从而评判其疗效及安全性。 结果：治疗8周后，临床研究显示治疗组在肾功改善积分、中医证候总疗效方面 优于对照组（P ＜0.05）；治疗后，治疗组肾功改善改善优于对照组（P ＜0.05）。 结论：十二味地黄汤对高血压患者早期肾损害方面有显著保护作用。 关键词 十二味地黄汤；高血压患者；肾损害；临床研究 To Observe the Clinical Efficacy of Shi Er Wei Di Huang Decoction in the Early Stage Hypertensive Nephropathy Specialty: Internal Medicine of Traditional Chinese Medicine Author: Sun Ningning Tutor: Prof.Lu Xiaohui Abstract Objective: To observe the clinical efficacy of shi er wei di huang decoction in the early stage hypertensive nephropathy. Methods:60 cases of the early stage hypertensive nephropathy were randomly divided into treatment group and control group, the treatment group of 30 patients treated with routine treatment and shi er wei di huang decoction ，and the control group of 30 patients only treated with routine treatment. Before treatment, respectively, underwent blood pressure measurement, urine trace protein, and renal function laboratory tests, the observed blood pressure changes, symptoms, signs of change of the level of renal function before and after treatment, in order to judge their efficacy and safety. Results: After 4 weeks of treatment, clinical studies have shown treatment group improved in renal function points, designate the total effect of TCM syndrome than the control group (P0.05). The clinical study showed that the treatment group was better than the control group in the early stage hypertensive nephropathy. Conclusion: the treatment of shi e