肾盂移行细胞癌伴破骨细胞样巨细胞肿瘤1例及文献复习.pdfVIP

实用医药杂志2008年03月第25卷第03划frac J Med＆Pharm．Vol 25，2008—03 No．03 · 259· 临床研究 肾盂移行细胞癌 · 论 著· 伴破骨细胞样巨细胞肿瘤l例及文献复习 蒋艳霞(!)于文娟② 张 伟(!)孙显路 (①青岛大学医学院附属医院病理科，山东青岛 266003； 匕京大学医学院病理科，北京 100850) [摘 要l 目的 探讨伴破骨细胞样巨细胞肿瘤的肾需移行细胞癌的临床病 学特征。方法 对 l例伴 破骨细胞样巨细胞的肾 移行细胞癌进行临床病理学分析及免疫组化研究，并复习相关文献。结果 患 者男性，51岁。肿物位于右侧肾 内．约3．0crux2．5cmx1．5era，灰白色，蕈伞状。镜下：肿瘤组织…典型的Ⅱ 级移行细胞癌及破骨细胞样肿瘤两种成分组成，混杂存在，末见移行。免疫组织化学：癌成分表达CK7、CK (AE1／AE3)及EMA阳性，灶性表达p53；破骨细胞样巨细胞及单核肿瘤细胞成分表达波形蛋白，CD68，少 数异型单核肿瘤细胞呈CK(AEI／AE3)及EMA阳性， CK7及p53均阴性。结论 伴破骨细胞样巨细胞 肿瘤的肾盂移行细胞癌应视为移行细胞癌的一个特殊组织学类型．破骨细胞样巨细胞肿瘤成分的出现可 能提示肿瘤更具侵袭性，预后不良。 【关键词]肾盂肿瘤 破骨细胞样巨细胞肿瘤 免疫组织化学 [中图分类号J R737．1 l文献标识码J A Transitional cell carcinoma of the renal pelvis associated with 0ste0clast—like giant cell tumor： a case report and review of the literature JIANG Yan—xia ，YU Wen-juan，ZHANG Wei，et a1． Department of Pathology，the Affiliated Hospital of Medical College of Qingdao University，Qingdao 266003， China 【Abstract】 Objective To explore the clinicopa【hologic features of transitional cell carcinomas of renal pelvis associated with osteoclast-like giant cell tumor．Methods The clinjcopa【hologic data of a case of transitional cell carcinoma with osteoclast-like giant cell tumoi’of the renal pelvis was reviewed and immunohistochemical staining was performed using antibodies against CK7，EMA，Vimentin，CD68，p53 on the dewaxed sections and review of related literature．Results The patient was 5 1-year—old male，his tumor was located in the right renal peL，is，and the size of the tumor was 3．0cm x2．5cm x 1．5cm．The tumor was grossly gray—white in color and caulmower—shaped in appearance．Histologically，the tumor was composed of transitional cell carcinoma alld osteoclast-like giant cell tumor．1mmunohistochemical stud