美替洛尔（Esmolol）.docVIP

美替洛尔（Esmolol） Esmolol [name of drug] US general name for bisoprolol English Name: Metipranolol Other name: Hydrochloride, Beta-Ophtiole, and Metipranolol [clinical application] This function can be used for contraceptives reduce intraocular pressure: 1. high intraocular pressure. * (1). 2. chronic open-angle glaucoma, non crystalline glaucoma, and other special types of glaucoma, such as cystic glaucoma, pigmented glaucoma, congenital glaucoma and hemorrhagic glaucoma. * (1). 3. intraocular pressure decreased after cataract extraction. * (1). [pharmacology] 1. the pharmacodynamics of the drug for non selective beta adrenergic receptor blockers, the (2) - mainly through reducing the real generation of water to reduce intraocular pressure, its role is specific beta adrenergic receptor blocking effects based on. * (1) from this aqueous drugs also increased slightly, this effect may be related with the decreased root of iris ciliary body blood flow. * (2). 2. the pharmacokinetics of the drug by 5% (1). The corneal absorption, the initial reaction of glaucoma 0.5-3 hour, reached the peak effect of 2-7 hours. * (2) a single agent to give the medicine, the duration of glaucoma for at least 24 hours. * (2) this medicine is one of the major metabolites of deacetyl metipranolol, the same effect as the original drug. * (1) this medicine can stick to the corneal and ocular structures, the pharmacokinetic half-life is about 3 hours, the pharmacodynamics half-life of up to 18 hours. * (1). [matters needing attention] 1. contraindications (1) allergic to the drug. (2) patients with bronchial asthma. (3) patients with obstructive pulmonary disease. (4) bronchial hyperresponsiveness. (5) patients with congestive heart failure. (6) severe bradycardia. * (1) - (7) II to III degree atrioventricular block. * (2) - (8) were corneal dystrophy. * (1) - (9) patients with cardiogenic shock. * (2). 2. caution (1) diabetic patients (increased insulin induced hypoglycemia). (2) hyperthyroidism