HLA-DR4基因检测与类风湿关节炎病情的关系（The relationship between hla-dr4 gene detection and rheumatoid arthritis）.docVIP

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HLA-DR4基因检测与类风湿关节炎病情的关系（The relationship between hla-dr4 gene detection and rheumatoid arthritis）.doc

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HLA-DR4基因检测与类风湿关节炎病情的关系（The relationship between hla-dr4 gene detection and rheumatoid arthritis）

HLA-DR4基因检测与类风湿关节炎病情的关系（The relationship between hla-dr4 gene detection and rheumatoid arthritis） Relationship between HLA-DR4 gene detection and rheumatoid arthritis 2010-12-14 Zhang Jinqiao, Wang Jinkai, Wu Weiwei, Zhang Jingui There is no specific index for the diagnosis of rheumatoid arthritis (RA), and there is a lack of objective basis for the evaluation of prognosis. We use the gene distribution in Hebei Han nationality rheumatoid arthritis in HLA-DR4 and its subtype determination of HLA-DRB1.0405 amplification method showed that the HLA-DR4 gene is one of the ideal index for early assessment of prognosis, report as follows now. 1 data and methods 1.1 general information 260 patients of Han nationality in Hebei from 1996 to 1997 in our hospital department of rheumatism in our hospital have rheumatic symptoms, of which 180 cases were diagnosed with RA, all cases are in line with the American College of Rheumatology (ARA) criteria for the diagnosis of rheumatoid arthritis arthritis, revised in 1987 1, male 40 cases, female 140 cases, male: female = 1: 3.5. The age ranged from 19 to 67 years old, the average (39.9 + 14.3) years of age, the disease course ranged from 0.5 to 20 years, the average (4.5 + 3.9) years. The control group consisted of 100 health workers from Hebei Han nationality. There were 30 males and 70 females, aged 35~63 years, with an average of (44.4 + 8.4) years. 1.2 method 1.2.1 observation indicators include: ESR, titers of rheumatoid factor (RF), the time of morning stiffness, joint swelling and tenderness index Richie / 2, wrist X-ray score 3. Determination of 0405 1.2.2 HLA-DR4 and HLA-DRB1 respectively. The apparatus analysis method and SSP restriction fragment length polymorphism PCR ~. Sequence specific primers were produced by Shanghai Zhongya biologicals. 1.2.3 statistical treatment: Chi square test was used for the comparison of rates, and clinical and laboratory indexes were checked by t test or T test (). Multiple regression was ai