降压饮对老年高血压病(1、2级)内皮素水平的影响和降压疗效观察.pdfVIP

提 要 目的：通过观察治疗前后血压及内皮四项值的变化，探讨内皮素在老年高血压病 中的发病机制，观察降压饮临床疗效，为临床应用提供理论依据。 方法：选取符合标准的60例老年高血压患者随机分为2组，治疗组30例，对照 组 30 例。治疗组给予降压饮口服联合西药缬沙坦降压，对照组给予单药缬沙坦降压 治疗。疗程8周。观察用药前后患者血压、内皮四项及症候积分的变化。 结果：治疗组显效 12 例，有效 14 例，无效 4 例，总有效率 87%。对照组显效 8 例，有效 14例，无效8例，总有效率73%，组间比较有显著性差异（P0.05）。两组 血压治疗前后有显著性差异（P0.01），组间比较有显著性差异（P0.01）。治疗组症 候改善总有效率90.0%，对照组总有效率为66.7%，组间比较有显著性差异 （P0.05）。 ET-1、PGF1a、TXB2、NO 治疗前后两组有显著差异（P0.01）,组间比较有显著性差 异（P0.05）。 结论：降压饮能明显降低老年高血压患者血压，改善临床症状及内皮素等血管活 性物质代谢，保护血管内皮。 关键词 降压饮；老年高血压；内皮素；疗效观察。 Jiang Ya Yin of endothelin levels and antihypertensive effects observed in elderly hypertensive patients (level one and two) Speciality: Geriatrics，internal medicine of TCM Author:Sui Cunsen Tutor:Li Rui Abstract Objective:To observe blood pressure and four endothelin changes before and after treatment, investigates endothelin in elderly patients with hypertension in the pathogenesis and observe the clinical efficacy of Jiang Ya Yin to provide a theoretical basis for clinical application. Method:Selected 60 cases of elderly patients with hypertension were randomly divided into 2 groups,treatment group of 30 cases,control group of 30 cases. Treatment group was given the Jiang Ya Yin orally combined with Western medicine Valsartan of 8 weeks, the control group received single-drug Valsartan treatment of 8 weeks. To observed before and after treatment the patients blood pressure, four endothelin and the syndrome score of change. Results: The treatment group have 12 markedly cases,14 effective cases, 4 invalid cases, the total efficiency of 87%. The control group have 8 markedly cases, 14 effective cases, 8 invalid cases, the total efficiency of 73%,and between the two groups have significant