超敏c-反应蛋白与糖尿病及其心血管并发症关系 - 中国现代应用药学.pdfVIP

·综 述 · 炎症标志物 C 反应蛋白、超敏 C-反应蛋白与糖尿病及其心血管并发症 关系研究概述 聂绪强 1 ，陈怀红 2 ，卞卡 1,3*(1 ．上海中医药大学穆拉德中药现代化研究中心，上海 201203 ；2.浙江大学医学院附属二院，杭州 310009 ； 3.美国德克萨斯大学休斯敦医学院综合生物及药理学系，德克萨斯大学分子医学研究所，美国 休斯敦 TX77030) 摘要：C-反应蛋白(C-reactive protein, CRP) 是体内最常见的急性时相反应蛋白，作为一种炎性标志物已被确认是糖尿病 心血管事件的独立预测因子，其升高与糖尿病心血管事件密切相关。超敏 C-反应蛋白(high sensitivity C-reactive protein, hs-CRP)较标准 CRP 对糖尿病及其心血管并发症的危险性分析更为敏感，hs-CRP 已经被多项前瞻性研究证实是未来发生 心血管事件的强烈预测指标。笔者就 CRP ，hs-CRP 与糖尿病及其心血管疾病的关系予以综述。 关键词：C-反应蛋白；超敏 C-反应蛋白；糖尿病；心血管疾病 中图分类号：R962.1 文献标志码：A 文章编号：1007-7693(2011)01-0026-05 Role of Inflammatory Markers C-reactive Protein, High Sensitivity C-reactive Protein in Diabetes and Its Cardiovascular Complications 1 2 1,3* NIE Xuqiang , CHEN Huaihong , BIAN Ka (1.Murad Research Center for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 2.The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China;3.Department of Integrative Biology and Pharmacology, Institute of Molecular Medicine, University of Texas Medical School, Houston TX77030, USA) ABSTRACT: C-reactive protein(CRP) is the most common acute phase response proteins in the body. As an inflammatory marker for diabetes has been identified as independent predictors of cardiovascular events, and which is closely related to cardiovascular events and diabetes. High sensitivity C-reactive protein (hs-CRP) is more sensitive than the standard CRP for cardiovascular complications of diabetes and its risk analysis, hs-CRP have been proved to be a strong predictor of cardiovascular events by a number of prospective studies. This article will introduce recent studies on the relationship among CRP, hs-CRP, diabetes mellitus and cardiov