蚕丝丝素蛋白材料的生物降解性能研究进展 - 《丝绸》杂志社.pdfVIP

Vol.48 第48卷 No.05, May. 2011 2011年05月 第05期 研究与技术 蚕丝丝素蛋白材料的生物降解性能研究进展 徐亚梅，李明忠 (苏州大学 纺织与服装工程学院，江苏 苏州 215021；现代丝绸国家工程实验室，江苏 苏州 215123) 摘要：丝素蛋白具有良好的生物相容性，但其用于制备组织工程支架等生物材料时，制成的材料还需具备的一个重要条件是其降解 速率与组织新生的速率相匹配。近年来国内外对丝素蛋白材料生物降解性能的研究进展表明，影响材料降解性能的因素包括材料的 形态、结构、植入点的机械和生理环境等。这些参数影响降解行为的具体过程和机理将是今后的研究重点。 关键词：蚕丝；丝素；生物材料；降解 中图分类号：TS149 文献标志码：A 文章编号：1001-7003(2011)05-0019-04 Research progress of biodegradation properties of silkworm silk fibroin materials XU Ya-mei, LI Ming-zhong (College of Textile and Clothing Engineering, Soochow University, Suzhou 215021, China; National Engineering Laboratory for Modern Silk, Suzhou 215123, China) Abstract: Silk fibroin has good biocompatibility. However, being used as tissue engineering scaffold, one of the key factors should be considered, which is the biodegradation rate of the silk fibroin should match the formation speed of a new tissue. This article reviewed the research development of biodegradation properties of silk fibroin biomaterials at home and abroad in recent years. The results show that influence factors of materials degradation performance include material form, structure, mechanical and physiology environment of the implant point, etc. The detailed process and mechanism of degradation behavior influenced by these parameters will be the research emphasis in the future. Key Words: Silkworm silk; Silk fibroin; Biomaterial; Degradation 生物医用材料是用于对生物体进行诊断、治疗、 素蛋白是作为生物医用材料的重要可选原料。 修复或替换其病损组织及器官，或增进其功能的新型 蚕