甲状旁腺功能减退症伴肌酶增高的相关因素和特点 - 南京医科大学.docVIP

甲状旁腺功能减退症伴肌酶增高的相关因素和特点 李红，佟强，谭娟，朱永芳，李雪琴 南京医科大学附属淮安第一医院老年医学科，江苏省淮安市 223300 【摘要】目的 分析伴肌酶增高的甲状旁腺功能减退症患者肌酶增高的相关因素和特点。方法 回顾性分析27例肌酶增高和39例肌酶正常的甲状旁腺功能减退症患者临床资料。结果 肌酶增高组与肌酶正常组在年龄、性别、病程、甲状旁腺激素水平、病因方面均无差别（p＞0.05），肌酶增高组患者血清钙浓度明显低于肌酶正常组(P＜0.01)；肌酶增高患者血清肌酸激酶（CK）和乳酸脱氢酶（LDH）明显增高(P＜0.01)；经补钙治疗，肌酶增高组患者血清肌酶水平逐渐降至正常。结论 甲状旁腺功能减退症血清钙浓度降低导致肌酶增高。 【关键词】甲状旁腺功能减退症；肌酶；钙； 【中图分类号】R582+.2 【文献标识码】A The related factors and feature of hypoparathyroidism accompanied by elevated serum muscle enzymes LI Hong, TONG Qiang, TAN Juan, ZHU Yong-fang, LI Xue-qin．Department of Geratology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China 【Abstact】Objective To analyze the related factors and feature of patients with hypoparathyrodism accompanied by elevated serum muscle enzymes。 Methods The clinical data of 27 patients of hypoparathyroidism with elevated muscle enzymes and 39 patients of hypoparathyroidism with normal muscle enzymes were analyzed retrospectively. Results There were no differences in age、gender、pathogenesis、etiopathogenisis and the level of parathormone between the group with elevated muscle enzymes and the normal group（p＞0.05）. Serum calcium concentration of the group with elevated muscle enzymes was significantly lower than the nomal group (P＜0.01)．The levels of CK、LDH were significantly higher in patients with hypoparathyroidism with elevated muscle enzymes (P＜0.01).After the treatment of calcium，the elevated enzymes gradually reduced to normal by the advance of serum calcium. Conclusion The reduce of serum calcium concentration elevates muscle enzymes in patients with hypoparathyroidism. 【Key words】Hypoparathyroidism；Enzymes；Calcium； 甲状旁腺功能减退症是由于甲状旁腺激素（parathormone,PTH）PTH降低。作为内分泌系统的一种常见疾病，国内对甲状旁腺功能减退症的研究报道较少，而甲状旁腺功能减退伴肌酶增高更是鲜有报道。现对甲状旁腺功能减退症伴肌酶升高患者的性别、年龄、病因、病程、血清肌酶谱、血清总钙浓度、心电图及心脏彩超等临床资料进行分析，进一步探讨肌酶增高的原因及其在甲状旁腺功能减退症临床诊疗中的意义。为甲状旁腺功能减退症的病情判定与疗效观察提供了新的思路。 一、对象和方法 I．对象：选取本院2000年1月至2012年12月间收治的甲状旁腺功能减退症患者66例，住院5-29天，平均住院（13.5±7.9）天；肌酶增高者27例，肌酶正常者