抗O与RF（Anti O and RF）.docVIP

抗O与RF（Anti O and RF） Clinically, rheumatoid factors, anti O, and ESR tests are the traditional laboratory tests for rheumatoid patients. So, what exactly is rheumatoid factor and anti O? Whats the point? 1: rheumatoid factor (RF) We have a protein in our body called a globulin. The antibody that we already know, known as immunoglobulin, is known as immunoglobulin (Ig). There are five kinds of antibodies in human body: IgG, IgM, IgA, IgD, IgE. We now know that rheumatoid factor is an autoantibody produced by denatured IgG antigen, that is, the autoantigen corresponding to rheumatoid factor is a denatured IgG molecule. Rheumatoid factors are not unique to rheumatoid patients, but this problem was first discovered in studies of rheumatoid arthritis and is therefore called rheumatoid factor. Rheumatoid factors can be divided into two naturally occurring and RA specific. The naturally occurring rheumatoid factor, which has only one form of IgM and is low in serum titers, can often occur in healthy elderly humans. And RA specific rheumatoid factor, serum titer is high, in addition to the main type IgM, there are IgG, IgA type. Because type IgM is considered to be the major type of rheumatoid factor, approximately 80% of rheumatoid arthritis patients are rheumatoid arthritis. At the same time, because type IgM rheumatoid factor has the characteristics of high coagulation and easy to precipitate, it is mainly used to determine type IgM rheumatoid factor in clinic. Latex agglutination and enzyme-linked immunosorbent assay were used. In clinical, we can encounter rheumatoid factor, but also check the specific immunoglobulin project, in order to further understand the patients in vivo rheumatoid factor type. There are also information, with IgM-RF, IgG-RF, IgA-RF such argument, that is specific to the molecular types of rheumatoid factors, After a lot of research, generally considered in the pathogenesis of rheumatoid factor in rheumatoid arthritis: rheumatoid factor IgM, may