口腔癌淋巴管密度检测及其临床意义.pdfVIP

. 134. 北京口腔医学 2∞8 年第 16 卷第3 期 Beijing Journal of Stomatology June 2∞8 ， Vol. 16 , No.3 口腔癌淋巴管密度检测及其临床意义 袁晓红刘晓勇王凤光汪育苗 [摘要] 目的 探讨口腔癌组织中淋巴管密度(LVD) 与颈淋巴结转移及其它临床病理参数之间的关系。 方法 选择56 例口腔鳞状细胞癌石蜡组织标本，采用免疫组化方法检测淋巴管内皮标志物D2-40及淋巴管内皮透 明质酸受体-1(LYVE-l) 在口腔癌中的表达，计算口腔癌中的 LVD ，并进行统计学分析，观察 LVD 与颈淋巴结转移 及其它临床病理参数(性别、年龄、发病部位、T 分期、病理分级、浸润方式)之间的关系。结果 LYVE-l 染色显示， 癌内 LVD 在淋巴结转移组明显高于无转移组(P 0. 05) 0 LYVE-l 染色和D2-40 染色均显示癌内 LVD 与病理分级 呈正相关(P 0. 017) 0 LVD 与性别、年龄、发病部位、T 分期及浸润方式均无关。结论 对于口腔癌来说，癌内淋 巴管在肿瘤的浸润和转移中发挥重要作用。 [关键词] 口腔; 鳞状细胞癌; 淋巴管密度; D2-40; LYVE-l [中固号] R739.8 [文献标识码] A [文章编号] l(脱叫673X(2∞8 )03 -û 134-04 Clinical signifi四nce of Iymphatic v笛sel density in oral squamo皿ωU carcinoma 咒JANXiω-Iwng ， UU X阳-yong ， WANG Feng-guang ， 阳NG Yu-miao. Department 01 pω， Iwlogy ， Capital Medical University Sclwol 01 Stomatology , Beijing 100050 , China [Ab耐act] Obj配创刊 To study the relationship between lymphatic vessel density (LVD) and cervicallymph node me阳t国is and other clinicopathological feat町es in oral s甲lamous cell carcinoma (OSCC) . Me也ods Immunohistochemical staining for lymphatic marker百 D2-40 and LYVE-l was used , and LVD was detected in fúty-six archival specimens of OSCC. 响le association between LVD and cervicallymph node metastasis and other clinicopathological features (gender , age , primary location , T stage , grade of pathology and fashion of tumor invasion) was statistically analyzed. Results Intratumoral LVD w国 higher in lymph node metastasis group than that in non-metastasis group (P O. 05). Intratumoral LVD w国 positively associated with grade of pathology (P O. 017). LVD w国 not associated with gender , age , primary location , T stage and fashion of tumor invasion. Conclusion Intratumoral lymphatics played a role in the in