补阳还五汤预先干预对大鼠脑死亡后心肺炎症细胞 - 天津中草药杂志社.pdf

中草药 ChineseTraditionalandHerbalDrugs 415 2010 5 757 1 2 3 1 1 1 陈 洁 , 曾耀英 , 曾慧兰 , 刘嘉雯, 苏泽轩,郝彤彤 ( 1 / , 510630; 2 , 510632; 3 , 510630) : Wistar 30 , 180~ 200 g, 3 :; :; :7 d, 1 ig ( 18 mL/ 100 g, 126 g/ kg) , 6 h, 80 mmHg,RTP R ( TNF) 1 (IL1) mRNA ,Western blotting TNF IL1 p38 ( pp38M APK) T NFIL1 mRNA p p38MAPK ( P 001) (P 005) , (P 001) , p38M APK : ; ; ; p38 :R2855 :A : 2010 Inhibitiononinflammatory cytokineexpressionsinheart andlung frombraindeathrats pretreatedwithBuyangHuanwuDecoction 1 2 3 1 1 1 HEN Jie , ZENG Yaoying , ZENG Huilan , LIU Jiawen , SU Zexuan , HAO T ongtong ( 1Department of Urology and Organ Transplantation, the First Affiliated Hospital of Jinan U niversity, Guangzhou 510630, hina; 2. Institution of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, hina; 3. Department of Hematology, the First Aff iliated Hospital of Jinan University, Guangzhou 510630, hina) Abstract: Objective To observe the inhibition of inflammatory cytokine expressions in hearts and lungs from brain death (BD) rats pretreated with Buyang Huanwu Decoction (BYHWT ) . ethods Male Wistar rats, weighing from 180 to 200 g, were randomly divided into three experimental groups: control group (n = 10) : hearts and lungs were gotten from normal rats after anesthesia; BD group ( n = 10) : rat brain death was gradually induced; BYHWT + BD group (n = 10) : 7 d before BD induction, rats were ig administered with BYHWT ( 1. 8 mL/ 100 g) once daily. Six hours after successful onset of BD, only the rats whose mean