磷酸钙骨水泥药物缓释载体的研究进展.pdfVIP

No．3 陕西科技大学学报 Ju 2008 V0I．26 JOURNAL OF SHAANXI UNIVERSITY OF SCIENCETECHNOLOGY · 25· 文章编号：1000—5811(2008)03—0025—05 PRoGRESS oN CALCIUM PHoSPHATE CEMENT PREPARED AS DRUG DELIVERY SYSTEM LI Juan-ying。HUANG Jian-feng。CAO Li—yun (SCh~I of Materials Science and Engineering，Shaanxi University of ScienceTechnology，Xi an 710021， China) Abstract：Calcium phosphate cement(CPC)use as an outstanding skeletal defect rehabilitate material was reported that it has been widely used in clinical practice because of its excellent properties such as biocompatibility，bioactivity，self-setting and releasing and so oil．The latest progress on calcium phosphate cement prepared as drug delivery system such as its re— lease kinetics，effective factors and physiochemical properties were reviewed．And it is also pointed out that the existing problems and the future research direction． Key words~calcium phosphate cement；drug delivery；kinetics；physicochemical properties CLC Number：R318．08；R944 Docum ent Code：A ． 0 Introduction Calcium phosphate cement(CPC)is one of the most important biomaterials for medical and dental applications because of its excellent properties such as the biocompatibility，bioactivity，self-setting，in— jectable and plasticity and so on．Meanwhile，the multi—porous structure makes it grow itself through the bone tissue when implanted in the body．As drug delivery system．the clinical study indicates that CPC has distinct curative effects in curing and preventing osteoporosis，bone arthritis，bone trauma and canc— er of bone，etc．due to its mild self-setting conditions．When repaired and filled in the bone damnifica— tion，the CPC can also release the drugs to local t