综述· 基于“异类相制”理论探讨雷公藤肝毒性配伍 - 天津中草药杂志社.pdf

中草药 Chinese Traditional and Herbal Drugs 第 45 卷 第 18 期 2014 年 9 月 ·2711 · ·综 述· 基于“异类相制”理论探讨雷公藤肝毒性配伍减毒的作用 1 1 1 1 1, 2* 张 静 ，江 莹 ，王 芳 ，张 贺 ，孟 楣 1. 安徽中医药大学，安徽 合肥 230038 2. 安徽中医药大学第一附属医院，国家中医药管理局中药制剂三级实验室，安徽 合肥 230031 摘 要：雷公藤作为治疗类风湿性关节炎等自身免疫性疾病的首选药，其所含化学成分复杂，具有抗炎、抗肿瘤、免疫调节 及抗生育等作用，是目前国内外研究的热点天然药物之一。但在使用中雷公藤所引起的肝损伤报道频繁发生，大大限制了其 临床应用。依据“异类相制”的中药配伍理论，对雷公藤肝毒性减毒方面的有关文献进行归类分析，提出雷公藤肝毒性配伍 减毒的组方原则，以期为提高雷公藤临床应用的安全性提供参考。 关键词：雷公藤；肝毒性；配伍减毒；异类相制；扶正制毒 中图分类号：R283.21 文献标志码：A 文章编号：0253 - 2670(2014)18 - 2711 - 05 DOI: 10.7501/j.issn.0253-2670.2014.18.026 Detoxicity effect of hepatotoxicity of Tripterygium wilfordii by compatibility mechanism based on “diversity restriction” theory 1 1 1 1 1, 2 ZHANG Jing , JIANG Ying , WANG Fang , ZHANG He , MENG Mei 1. Anhui University of Chinese Medicine, Hefei 230038, China 2. The First Hospital Affiliated to Anhui University of Chinese Medicine, Hefei 230031, China Abstract: Tripterygium wilfordii as the preferred treatment drug for autoimmune diseases such as rheumatoid arthritis, with complicated chemical composition and anti-inflammatory, antitumor, immune regulation, and anti-reproductive function, is one of the hot natural medicines both at home and abroad. However, liver damage caused by T. wilfordii is reported frequently, which greatly limits its clinical application. In this paper, we collect and summarize the researches on the hepatotoxicity and compatibility of T. wilfordii in recent years based on the “detoxicity compatibility” theory of Chinese medicine compatibility. Meanwhile, we propose the principle of prescription to reduce the hepatotoxicity of T. wilfordii by compatibility mechanism, with a view to improve the security