呼吸系统念珠菌感染菌种分布及耐药性研究.docVIP

呼吸系统念珠菌感染菌种分布及耐药性研究【摘要】 目的 了解中山大学附属第三医院呼吸系统念珠菌感染的菌种分布及药敏情况,为控制呼吸系统念珠菌感染提供依据。方法 对2006~2008年间,从我院呼吸系统感染性疾病患者中分离到的念珠菌,采用API-20Aux和ATB FUNGUS 进行鉴定和药敏实验,所得结果进行统计分析。结果 131株念珠菌中,检出率最高的前三种是白色念珠菌(55.0%)、光滑念珠菌(20.6%)和热带念珠菌(8.4%)等,各种念珠菌对两性霉菌素B和伊曲康唑敏感率最高,达97.7%和95.1%,咪康唑敏感率最低,只有65.8%。结论 呼吸系统念珠菌感染是以白色念珠菌感染为主,各种念珠菌对两性霉菌B和伊曲康唑敏感率高但中介株或耐药株有逐年上升趋势,对其他抗真菌药有不同程度的下降,应引起临床和实验室高度重视。 【关键词】呼吸系统;念珠菌;药敏试验 Species distribution and antifungal resistance of Candida in respiratory infection patients WANG Tan-feng,XI Yun.The Third Affiliated Hospital Of Sun Yat-sen University,Guangzhou 510630,China 【Abstract】 Objective To investigate distribution and antifungal resistance of Candida isolated from respiratory infection patients in the Third Affiliated Hospital of Sun Yat-sen University.Methods The strains of Candida were isolated from respiratory infection patients in our hospital and identified with API-20Aux strip.Drug sensitive test of Candida were detected with ATB-Fungus strip.Results Among 131 strains examined,the most common Candida isolated rate was Candida albicans(55.0%),Candida glabrata(20.6%),Candida tropicalis(8.4%).The Candida had higher sensitivity to amphotericin B(AMB)and itraconazole,their rates of susceptibility were 97.7%and 95.1%respectively,but the sensitivity rate to Miconazole was relatively low(65.8%).Conclusion The pathogens causing fungus infection are mainly Candida albicans in our hospital and it shows more sensitive to amphotericin B(AMB)and itraconazole,but the intermediate strains and resistant strains increase annually.Serious attention should be paid to drug-resistant Candida isolated from respiratory infection patients. 【Key words】 Respiratory Infection; Candida; Drug sensitive 念珠菌是咽部常驻寄生菌,正常情况下对人体无害。近些年来,由于广谱抗生素不规范使用以及激素类药物、化疗手段等在临床上广泛应用,使得患者呼吸系统菌群失调,念珠菌大量生长,从而引起呼吸道念珠菌感染,感染率日益上升且病情进一步加重,给临床工作造成巨大压力。为了解我院呼吸系统念珠菌感染情况,本文对于2006年6月到2008年5月间,在我院就诊患者的呼吸系统标本中分离到的念珠菌及药敏结果,进行统计分析,旨在为临床控制呼吸系统感染提供依据,报告如下。 1 材料与方法 1.1 标本来源 2006年6月到2008年5月期间,在我院就诊的呼