脑脊液屏障和血.ppt

The End. * Special Circulation Qiang XIA (夏强), MD PhD Department of Physiology Room C518, Block C, Research Building, School of Medicine Tel:Email: xiaqiang@zju.edu.cn System Overview The blood flow to organs depends on ⒈ The difference between aortic pressure and central venous pressure ⒉ The diastolic and systolic state of blood vessel in this organ The blood flow to individual organs must vary to meet the needs of the particular organ, as well as of the whole body Neural, myogenic, metabolic, and endothelial mechanisms control regional blood flow Neural mechanism: Autonomic nervous system (sympathetic division) Myogenic mechanism: Metabolic mechanism: PO2, pH, etc. Endothelial mechanism: NO, EDHF, PGI2, ET, EDCF, etc. System Overview Autoregulation in the vessels of heart, brain, skeletal muscle, and kidneys Blood pressure Cardiac output Local blood flow Local control in the vessels of heart, brain, skeletal muscle during exercise Relaxing or contracting VSMCs Neural mechanism: Autonomic nervous system (sympathetic division) Myogenic mechanism: Metabolic mechanism: PO2, pH, etc. Endothelial mechanism: NO, EDHF, PGI2, ET, EDCF, etc. System Overview Resting vasomotor tone ECs VSMCs Gap junction Electrical and chemical signalling Vasomotor control Sophisticated feedback, Mechanical forces, etc. Local circulation System Overview I. Coronary Circulation 冠脉循环 II. Cerebral Circulation 脑循环 Coronary circulation Heart: view from front Coronary circulation Heart: view from diaphragm 左冠状动脉 右冠状动脉 供血区域 左心室前部 左心室后部 和左侧部 和右心室 回流途径 冠状窦→右心房 心前静脉→右心房 Coronary circulation —— Provides blood flow to the heart 1. Heart muscle consumes as much O2 as does equal mass of SM