喷雾干燥技术在口服固体制剂生产中的应用（Application of spray drying technology in the production of oral solid preparations）.docVIP

喷雾干燥技术在口服固体制剂生产中的应用（Application of spray drying technology in the production of oral solid preparations） The spray drying technology with the spray method, make the material to droplet disperse in the hot air flow, full contact materials and hot air, heat and mass transfer process in an instant, the solvent (including water and organic solvent) quickly evaporated into gas, to achieve the purpose of drying. The spray drying technology is widely used in the pharmaceutical industry in China, in the field of oral solid preparation, commonly used in high sensitive drugs and feed liquid concentration during the process of decomposition of drug drying. The obtained product has fine particle size, uniform distribution, good fluidity and instant solubility. Characteristics and classification of spray dryer Spray dryer is a kind of drying equipment that directly dry the solution or suspension into solid particles. The drying product can be directly obtained from the feed liquid, and the unit operation such as evaporation, crystallization, separation and pulverization can be avoided, and the utility model can be continuously and automatically produced, and the operation is stable. The drying methods, spray dryer gas-solid contact surface area, short drying time, dry time is 5 ~ 30s, suitable for drying heat sensitive materials. The dried product has good quality and can obtain 30~50 m particle, and the product has good fluidity and instant solubility. The disadvantages are that the size of the dryer is large and the heat transfer coefficient is low, which leads to low thermal efficiency and great power consumption. There are many kinds of classification methods of spray dryer, gas-liquid flow in flow, and can be divided into countercurrent and Francis; according to installation of the atomizer can be divided into spray type, spray type; according to the structure of the atomizer can be divided into centrifugal, pressure and airflow; according to whether gas heating cycle can b