DATA SHEET AUGMENTIN Medsafe（数据表安灭菌 Medsafe）.pdf

DATA SHEET AUGMENTIN ® Amoxicillin trihydrate/potassium clavulanate (syrups and tablets) Presentation AUGMENTIN Syrup 125: Glass bottles of off-white powder for the preparation of 100mL suspension. When reconstituted each 5mL contains potassium clavulanate equivalent to 31.25mg clavulanic acid with amoxicillin trihydrate equivalent to 125mg amoxicillin. When reconstituted the suspension is white/cream in colour. AUGMENTIN Forte Syrup 250: Glass bottles of off-white powder for the preparation of 100mL suspension. When reconstituted each 5mL contains potassium clavulanate equivalent to 62.5mg clavulanic acid with amoxicillin trihydrate equivalent to 250mg amoxicillin. When reconstituted the suspension is white/cream in colour. AUGMENTIN 500 Tablets: White to off white, oval shaped, film coated tablets, approximately 20mm x 9.5mm, engraved AC with a score line on one side and plain on the other side. Each tablet contains potassium clavulanate equivalent to 125mg clavulanic acid with amoxicillin trihydrate equivalent to 500mg amoxicillin. Pharmaceutical forms Syrup and tablets. Uses Actions AUGMENTIN (beta-lactam antibacterial penicillin co-formulated with a beta- lactamase inhibitor) is an antibiotic agent with a notably broad spectrum of activity against the commonly occurring bacterial pathogens in general practice and hospital. The beta-lactamase inhibitory action of clavulanate extends the spectrum of amoxicillin to embrace a wider range of organisms, including many resistant to other beta-lactam antibiotics. Pharmacodynamic properties Microbiology: amoxicillin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity against many gram-positive and gram-negative micro- organisms. Amoxicillin is, however susceptible to degradation by beta-lactamases and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes. Clavulanic acid