整合素β1β3α5β1和αvβ3在非小细胞肺癌侵袭和转移中的作用机制研究.docxVIP

整合素β1、β3、α5β1和αvβ3在非小细胞肺癌侵袭和转移中的作用机制研究【摘要】 目的：研究整合素β1、β3、α5β1和αvβ3在非小细胞肺癌发生、发展过程中的组织表达及侵袭和转移过程中的作用机制。方法：采用免疫组化SP检测法对57例非小细胞肺癌组织与12例正常肺组织石蜡标本中的β1、β3、α5β1和αvβ3表达情况做比较。采用SPSS10.0软件进行x2检验及Fisher精准概率法，P0.05认为有统计学差异。结果：整合素β1、β3、α5β1和αvβ3在非小细胞肺癌组织表达的结果分别为：43.9%，P=0.004；51.21%，P=0.004；70.59%，P=0.031；84.48%，P=0.037。结论：整合素β1、β3、α5β1和αvβ3在非小细胞肺癌侵袭和转移中，他们的肺癌组织表达结果均明显高于正常肺癌组织的16.68%，并且在对非小细胞组织中的表达由低到高分别是β1＜β3＜α5β1＜αvβ3。由此可得病理分级越低阳性表达率越高，高表达与非小细胞肺癌组织的恶性生物学特征相关。【关键词】整合素；非小细胞肺癌；生物合成【中图分类号】R734.2 【文献标识码】A 【文章编号】Role of integrin β1,β3,α5β1and αvβ3 in the invasion and metastasis of small cell lung cancer[Abstract] Objective: To study the effect of integrin β1, β3, α5β1 and αvβ3in the development of non small cell lung cancer. Methods: β1 cases of non small cell lung cancer tissues and 12 cases of normal lung tissues were detected by immunohistochemical SP method. The expression of 57, β1, β3, α5β1 and αvβ3were compared. Using x2 software to carry out the SPSS10.0 test and the Fisher precision probability method, P0.05 think there is a statistically significant difference. Results:the expression of integrin β1 ,β3, α5β1 and αvβ3 in non small cell lung cancer tissues were: 43.9%, P=0.004; 51.21%, P=0.004; 70.59%, P=0.031; 84.48%, P=0.037. Conclusions:integrin β1 , β3, α5β1 and αvβ3in the invasion and metastasis of non-small cell lung cancer, the expression of lung cancer tissue was significantly higher than that in normal lung tissue, and the expression in non small cell tissue from low to high were16.68%β1 β3 α5β1 αvβ3The lower positive expression rate was higher, and the higher expression was related to the malignant biological characteristics of non small cell lung cancer.【Keywords】Integrin; Non small cell lung cancer; Biosynthesis肺癌是导致死亡率非常高的常见恶性肿瘤。根据智研数据中心统计我国肺癌死亡率高达22.7%，而肺癌的治愈率却低于15%。在肺癌疾病研究中我们发现，整合素作为黏附分子，在肺癌疾病演变过程中发挥着重要的作用。整合素的黏附分子有α、β亚单位连接构成，不同的连接方式在肺癌组织中的阳性表达对非小细胞肺癌侵袭和转移有着重要的作用机理，因此，本文以β1、β3、α5β1和αvβ3为例分别试验，研究其对病理类型、淋巴转移、临床转移、病理分级和肿瘤大小方面的特征关系，以此得出结论，β1、β3、α5β1和αvβ3在非小细