血小板制剂制备与临床应用.pptVIP

Platelet Concentrates ? Prophylactic to prevent bleeding – Severe thrombocytopenic patients ? Treat active bleeding – PLT 5 – 10万/μL – PLT dysfunction Platelet Concentrates Biggest Issues for Transfusion Service 1.Increasing Need 2.Availability ? Short storage time (5 days) ? Sensitivity to low donations – Apheresis = donor recruitment – “Pooled platelets”: 4-6 whole blood / pool Platelets ? Prophylactic transfusions ( 50% ) – Severe thrombocytopenia – Prevent major bleeding – Clinical research ? Transfusion response ? Transfusion trigger ? Transfusion dose Transfusion Response