抗菌肽的研究进展 - 生命科学.PDF

20 4 Vol. 20, No. 4 2008 8 Chinese Bulletin of Life Sciences Aug., 2008 1004-0374(2008)04-0605-06 1 310014 2 ( ) 310018 Q5 16 A Progress on antimicrobial peptides 1 2 1 1 ZHU Ji , GAO Fei , YI Yu , CHEN Jian-shu, YING Guo-qing * (1 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; 2 ABON Biopharm (Hangzhou) Co., Ltd , Hangzhou 310018, China) Abstract: Resistance of microbial pathogens to antibiotics is an increasingly serious problem, which result in urgency for new type antibiotics development. Antimicrobial peptides have great clinical significance due to its character of small molecular weight, high thermal stability, broad-spectrum antimicrobial activity and the anti- microbial mechanisms different from traditional antibiotics. The research advances in antimicrobial peptides obtained from natural resource, enzymatic digestion of protein, chemical synthesis and gene engineering were summarized in this paper. Key words: antimicrobial peptide; enzymatic digestion of protein; gene engineering; chemical synthesis (antibacterial peptides, ABP)[1] 100, (1) (G- + ) (G ) (2) (3) 2008-01-30 2008-04-21