2型糖尿病合并非酒精性脂肪肝临床特征及危险因素研究.doc

2型糖尿病合并非酒精性脂肪肝临床特征及危险因素研究[摘要] 目的 探讨2型糖尿病（T2DM）合并非酒精性脂肪肝（NAFLD）的临床特点及危险因素。方法 记录两组患者的年龄、性别、身高（H）、体重（W）、血压（BP）、血肌酐（Scr）、血尿酸（UA）等指标，计算体重指数（BMI）=体重（kg）/身高（m2）及腰臀比（WHR）。比较T2DM合并NAFLD（A组，n=69）与T2DM不合并NAFLD（B组，n=75）的患者之间的临床特征。结果 两组患者的SBP、DBP、TG无明显差异（P＞0.05），A组患者年龄、BMI、FPG、TC、HDL-C、LDL-C、WHR、FINS均高于B组（P＜0.05）。BMI、LDL-C、TG是糖尿病脂肪肝形成的主要危险因素（P＜0.05）。结论 非酒精性脂肪肝是2型糖尿病的主要并发症，是独立于体重指数及脂肪分布类型以外的相关因素。 [关键词] 2型糖尿病；非酒精性脂肪肝；胰岛素抵抗；危险因素 [中图分类号] R587.1；R575.5[文献标识码] B[文章编号] 1673-9701（2011）20-52-02 Clinical Characteristics and Risk Factors of Type 2 Diabetes Mellitus Combined with NAFLD WANG XinliLIU YunxiaLV Hairui Department of Endocrinology， Xingyuan Hospital of Yulin City in Shanxi Province， Yulin 719000， China [Abstract] Objective To investigate the clinical characteristics and related factors of type 2 diabetes mellitus combined with nonalcoholic fatty liver disease （NAFLD）. Methods Patients were divided into two groups on the basis of wheather they had NAFLD complications. Age， sex， height （H）， weight （W）， blood pressure （BP）， serum creatinine （Scr） and blood uric acid （UA） were recorded， and BMI and WHR were calculated in the two groups. Clinical characteristics were compared between T2DM with NAFLD and without NAFLD. Results No significant differences （P＞0.05） were observed between the two groups on SBP， DBP and TG indexes. But several indexes including age，BMI，FPG，TC，HDL-C，LDL-C，WHR，FINS were remarkably higher than B group. BMI， LDL-C， TG were the main risk factors of fatty liver occurrence in patients with diabetes. Conclusion NAFLD is a major complication and correlative factor independent of body mass index and fat distribution types for patients with type 2 diabetes. [Key words] Type 2 diabetes mellitus； Nonalcoholic fatty liver disease； Insulin resistance； Risk factors 2型糖尿病合并非酒精性脂肪肝是由糖尿病引起的肝脏组织学和功能变化的病变。21%～78% 2型糖尿病患者可发生脂肪肝，部分患者继发脂肪性肝炎，甚至脂肪性肝硬化[1]。为了解2型糖尿病合并非酒精性脂肪肝患者的临床特征及危险因素，为临床治疗DFL提供依据，我们对我院69例T2DM合并NAFLD患者的临床资料进行比较分析，现报道如下。 1资料与方法 1.1临床资料