吸入麻醉药对气道高反应性抑制作用及机制探究.doc

吸入麻醉药对气道高反应性抑制作用及机制探究[摘要] 目的 观察研究吸入麻醉药对气道高反应性的抑制作用及其机制。 方法 回顾分析我院2007年1月～2008年1月入诊的60例行吸入麻醉的气道高反应性患者与同期60例常规治疗（静脉注射麻醉药）的有气道高反应性表现的患者的临床资料，观察比较两组患者气道阻力及肺顺应性在不同时间点的变化情况。结果 与初始值比较，观察组提高肺顺应性的效果及降低气管阻力的效果明显优于对照组的疗效（P＜0.05），吸入麻醉组肺顺应性提高的效果及气道阻力降低的效果明显高于对照组（P＜0.05）。结论 吸入麻醉药对气道高反应性具有抑制作用，临床手术时此法安全有效，值得推广。 [关键词] 吸入麻醉药；气道高反应性；抑制 [中图分类号] R614.2 [文献标识码] B [文章编号] 1673-9701（2011）36-76-02 The Inhibition and Mechanism Research of Inhaled Anesthetics on the Airway Responsieness YANG Weidong The Uropoiesis Kidney Hospital of Ningbo City in Zhejiang Province，Ningbo 315100，China [Abstract] Objective To explore the inhibitory effect and mechanism of inhaled anesthetics on the airway responsiveness. Methods Retrospective analysis the 60 patients with routine inhaled anesthesia airway hyperresponsieness from January 2007 to January 2008 and the clinical data of 60 cases patients had airway hyperresponsiveness whom used conventional treatment（intravenous anesthetics）in the same period. The airway resistance and pulmonary compliance in the changes of different time points of the two groups of patients were observed. Results Compared with the initial value，the effect of improving lung compliance and reduce the resistance of airway of the study group were significantly better than the control group（P＜0.05）. The effect of increased lung compliance and the effect of reduced airway resistance in the inhalation anesthesia group was significantly higher the control group（P＜0.05）. Conclusion Inhaled anesthetics had inhibition on airway hyperresponsiveness，the clinical surgery of this method is safe and effective，which is worthy to be popularized. [Key words] Inhaled anesthetics；Airway responsieness；Inhibition 气道高反应性是指气管对各种刺激呈高度敏感状态，表现出敏感而过强的支气管平滑肌收缩反应，引起气道狭窄和气道阻力增加，肺顺应性下降等[1]，从而引发咳嗽、胸闷、呼吸困难和喘息等症状。吸入麻醉药能直接作用于气管平滑肌，在临床上使用浓度范围内有直接舒张作用，有很好的临床使用价值。回顾分析我院2007年1月～2008年1月就诊的60例行吸入麻醉的气道高反应性患者与同期60例常规治疗（静脉注射麻醉药）的有气道高反应性表现的患者的临床资料，观察比较两组患者在不同时间点的气道阻力及肺顺应性的变化情况，比较两组疗效，试提出吸入麻醉药对气道高反应性的抑制作