生长抑素及参芎注射液联合应用治疗重症急性胰腺炎临床探究.docVIP

生长抑素及参芎注射液联合应用治疗重症急性胰腺炎临床探究[摘要] 目的：评价生长抑素和参芎注射液联合应用治疗重症胰腺炎的效果。方法：在41例重症胰腺炎患者中，21名患者为生长抑素、参芎注射液治疗组，20名患者接受为生长抑素，观察患者治疗前后APACHEⅡ评分的演变。结果：生长抑素和参芎注射液联合治疗组在 APACHEⅡ评分改善方面较单纯生长抑素治疗组疗效好（P＜0.05）。结论：参芎注射液和生长抑素联合应用治疗重症胰腺炎，可改善患者的预后。其机制可能与胰腺微循环的改善，局部炎症反应的减轻有关。 [关键词] 重症胰腺炎；参芎注射液；生长抑素；联合治疗 [中图分类号] R576[文献标识码]B [文章编号]1673-7210（2007）12（c）-094-02 Effects of somatostatin combined with salivae maltiorrhizae liguspyragine hydrochloride and glucose injection for severe acute pancreatitis CEHG Jun-tao CHEN Tao (The Affiliated Hospital of Hainan Medical College, Hainan570102, China ) [Abstract] Objective: To observe the effectiveness of somatostatin injection combined with salivae maltiorrhizae liguspyragine hydrochloride and glucose injection for severe acute pancreatitis(SAP). Methods: 41 patients with SAP were divided into two groups. 20 patients received a treatment with somatostatin. A therapy of somatostatin combined with salivae maltiorrhizae liguspyragine hydrochloride and glucose injection was performed in other group. Before and after the treatment for 7 days, APACHEⅡ were observed. Results：In treatment group, APACHEⅡ was improved more than other group.Conclusion: The treatment of somatostatin combined with salivae maltiorrhizae liguspyragine hydrochloride and glucose injection is effective for patients with SAP. [Key words] Severe actute pancreatitis;Somatostatin injiection;Salivae maltiorrhizae liguspyragine hydrochloride and glucose injection; Combined therapy 重症急性胰腺炎(severe acute pancreatitis, SAP)是一种由多因素诱发、累及多环节的急危重疾病，常并发多器官功能损害，进而继发多器官功能衰竭。研究表明生长抑素可以抑制胰腺的分泌，而参芎注射液具有改善胰腺微循环的作用。我们通过比较41例SAP患者的治疗效果，探讨生长抑素与参芎注射液联合应用在SAP治疗中的作用。 1 资料与方法 1.1 临床资料 2004年9月～2007年6月我院收治的SAP患者41例，其中男性26例，女性12例，年龄21～64岁。所有病例诊断均符合中华医学会消化病学会胰腺病学组2004年中国急性胰腺炎诊治指南（草案）中有关SAP的诊断标准。 41例患者随机分为两组。观察组21例，男16例，女5例；年龄21～64岁，平均40.6岁；对照组20例，男10例，女10例；年龄24～59岁，平均42.3岁。两组比较无显著性差异，具有可比性。 1.2. 方法 两组患者入院后均在采用包括禁食、持续胃肠减压、抗感染、抑酸、维持水电解质平衡及营养支持等综合治疗的基础上，生长抑素250 μg/h，微量泵维持静脉泵入。观察组加用参芎