血液储存时间对消化道肿瘤手术患者红细胞免疫功能影响-.docVIP

血液储存时间对消化道肿瘤手术患者红细胞免疫功能影响*[摘要] 目的 探讨血液储存时间对消化道肿瘤手术患者红细胞免疫功能的影响。方法 将30例消化道肿瘤手术患者分为两组，A组23例，输入储存时间＜14d的血液，B组7例，则输入储存时间＞14d的血液，采集患者输血前和输血后1、2 、3 和7d的血液分别检测红细胞-C3b受体红细胞免疫复合物（RBC-IC）和红细胞超氧化物歧化酶（RBC-SOD）的水平。结果 患者输入储存时间＜14d的血液时RBC-C3b， RBC-SOD有所增加， RBC-IC则降低；而输入储存时间较长（＞14d）的血液时，其输血后较输血前的RBC-C3b，RBC-SOD有所降低， RBC-IC则增加。结论 血液在储存过程中随时间延长红细胞免疫黏附功能降低，而术后患者由于创伤及全身炎症反应致免疫功能低下，在输血治疗时应尽可能输入储存时间少于14d的血液，以帮助患者增强免疫功能，利于患者的康复。 [关键词] 血液储存；消化道肿瘤；手术患者；红细胞免疫功能 [中图分类号] R735 [文献标识码] B [文章编号] 1673-9701（2011）32-41-03 The Influence of Blood Storage Time on Erythrocyte Immune Function of Postsurgical Patients with Gastrointestinal Cancer LEI Yuji PENG Yi LV Haitao The First People’s Hospital of Hengyang City in Hunan Province, Hengyang 421002, China [Abstract] Objective To investigate the influence of blood storage time on the erythrocytes immune function of postsurgical patients with gastrointestinal cancer. Methods Tirty patients were divided into 2 groups, one consists of 23 patients used blood whose storage time was short than 14 days, the other one consists of 7 patients used blood whose storage time was longer than 14 days. Took patients? blood at the following time, before transfusion, 1 day after transfusion, 2 day after that, 3 day after that and 7 day after that, and checked the levels of RBC-C3b, RBC-IC and RBC-SOD respectively for the blood sample above. Results Patients who were transfused wit blood reserved within 14 days, got higher RBC-C3b and RBC-SOD, Conversely, their average RBC-IC were decreased, While the patients who were transfused with blood reserved longer than 14 days, got lower RBC-C3b and RBC-SOD, On the contrary, their RBC-IC were increased, Conclusion Erythrocytes surface membrane receptors and RCIA are decreased during blood reserve process. After surgery, due to wound and inflammatory reaction, immune function of patients is low, thus they should be transfused with blood which storage time is within 14 days at best, in order to increase immune fun