颅内外动脉狭窄患者血管内支架成形术前后血清超敏C反应蛋白水平的变化.pdfVIP

· 6- J Clin Neurol，February 2008，Vo1．21。No．1 · 论著 · 颅内外动脉狭窄患者血管内支架成形术 前后血清超敏C反应蛋白水平的变化 王嗣欣，应凤博，胡亚军，周丽红，高燕军，米艳娟，刘志华，陈启东 【摘要】 目的 观察颅内外动脉狭窄患者血管内支架成形术前后血清超敏C反应蛋白(hs．CRP)水平的 变化。方法 对25例接受血管内支架成形术的颅内外动脉狭窄患者术前、术后3 d及术后6～12个月的血 清hs·CRP水平进行检测，并对术后6～l2个月血管再狭窄及无再狭窄患者的hs．CRP水平进行比较。结果 25例颅内外动脉狭窄患者血管内支架成形术后3 d及术后6～l2个月的血清hs．CRP水平均明显高于术前 (均P0．05)，术后3 d血清hs·CRP水平与术后6～l2个月比较差异无统计学意义(P0．05)；再狭窄组术 后6～l2个月时血清hs·CRP水平明显高于无再狭窄组(P0．05)。结论 颅内外动脉狭窄患者血管内支架 成形术后血清hs．CRP水平增高，出现术后血管再狭窄的患者升高更显著。 【关键词】动脉狭窄；再狭窄；支架；超敏C反应蛋白 【中图分类号】R543．4 【文献标识码】A 【文章编号】1004．1648(2008)01-0006-02 Changes of serum hs-CRP level before and after stent·assisted angioplasty in pafien~ with intracranial and extracranial arteries咖osis WANG Si·xin，YING Feng·bo，HU Ya-jun，et a1．Department ofNeurology，the 够 Z池 d Hospital ofChengde Medical College，Chengde 067000，China Abstract：Objective To observe the changes of serum high·sensitivity C·reactive protein(hs·CRP)level before and after stent·assisted angioplasty in patients with intracranial and extracranial arteriestenosis．Methods The level of serum hs·CRP were determined in 25 patients treated with cerebral a~ery stenting before stent implantation，3 days after stent implantation and during 6～12 months of f0U0w·up．The serum levels of hs·CRP in non·restenosis group and restenosis group 6～12 months after stent implantation were also compared．Results The levels of serum hs·CRP 3 days after stent implantation and during 6～12 months of follow·up were higher than those before operation (all P0．05)，but there Was no difference between 3 days after stent implantation and 6～12 months of follow·up (P0．05)．The level of serum hs·CRP in restenosis group Was higher than that in non·restenosis group during 6～ 12 months of follow·up(P0．05)．Conclusions The level of serum hs-CRP is increased