银杏叶注射液对急性冠状动脉综合征患者血浆神经肽Y、神经降压素水平的影响.pdfVIP

第32卷 黑 龙 江 医 学 、，o1．32，No．2 92 2OO8年第2期 HEI LONG JL G MEDICAL JOURNAL Eeb．20o8 银杏叶注射液对急性冠状动脉综合征患者 血浆神经肽Y、神经降压素水平的影响 苏伟青，李树裕，冯日芳，陈肖坚，姚林伶，梁 青 (广东省廉江市人民医院心内科，广东廉江524400) 摘要：目的 观察银杏叶注射液对急性冠状动脉综合征(ACS)患者血浆神经肽Y(NPV)~神经降压素 (NrI)水平的影响。方泫 用放射免疫分析法测定73例ACS患者血浆NI)Y、NT的水平，并以60例健康者作 对照，观察ACs患者常规治疗及在其基础上加用银杏叶注射液静注后NI)Y、NT的水平变化。结果 ACs患 者血浆NPY和NT水平均明显高于对照组(P0．05)，常规治疗及加用银杏叶注射液治疗后NPY水平均有 明显下降，且银杏叶注射液组较常规治疗组下降更显著(P0．05)。结论 银杏叶注射液可明显降低ACs 患者血浆NPY、NT水平，对改善患者心肌缺血及心功能有重要作用。 关键词：银杏叶；急性冠状动脉综合征；血浆神经肽Y；神经降压素 学科分类代码：320．2410 中图分类号：R541．4 文献标识码：A 文章编号：1004—5775(20o8)02—0092—03 The Infection of Ginkgo Biloba Injection on the Plasma Neurotens in and Neuropeptide Y in Patients with Acute Coronary Syndrome SU Wei—qing，LI Shu—yu，FENG Ri—fang，et a1． (Department Cardilogy，The People’S Hospital ofLianjiang City，Lianjiang 524400，China) Abstrast：Objective To observe the infection ofGinkg0 Biloba Injection(GBI)on the plasma Neuropeptide Y(NPY) and Neurotensin(NrI)in patients with Acute Coronary Syndrome(ACS)．Methods Levels of plasma M and NT were measured by radioimmunoassay(mA)in~rventy—three ACS patients and sixty normal subjects．We ob~Ive the differ． ences between treatment with and without GBI administered intravenously and the level cIla s of NI)Y and NT after treamaent with GBI．Results Plasma NPY and NT levels in ACS patients are significantly higher than normal subjects (P0．05)；Both NI)Y and NT are decreased after normal treatment and treatment with GBI，and it is mole evident in treatment with GBI(P0．05)．Conclusion Both NPYl N11 participate in the pathophysical progression of ACS，GBI can clearly lower levels of NPY and NrI．GBI antagonizes the effects ofNPY on constricting vessels and it plays an impor． tant rol