FLT3基因序列Homosapiensfms-relatedtyrosinekinase3(FLT3).docVIP

Homo sapiens fms-related tyrosine kinase 3 (FLT3), RefSeqGene on chromosome 13 NCBI Reference Sequence: NG_007066.1 FASTA?Graphics LOCUS NG_007066 104953 bp DNA linear PRI 11-JUN-2012 DEFINITION Homo sapiens fms-related tyrosine kinase 3 (FLT3), RefSeqGene on chromosome 13. ACCESSION NG_007066 VERSION NG_007066.1 GI:160358346 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 104953) AUTHORS Parcells,B.W., Ikeda,A.K., Simms-Waldrip,T., Moore,T.B. and Sakamoto,K.M. TITLE FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia JOURNAL Stem Cells 24 (5), 1174-1184 (2006) PUBMED REMARK Review article COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Rod Docking. The reference sequence was derived from AL356915.19, AL445262.7 and AL591024.14. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytopla