滚轮微针预处理对利多卡因局麻桡动脉穿刺镇痛效果的影响.doc

回复2014.2月专家意见:（谢谢专家指导，我逐条意见回复） 1.微针阵列具有无痛、等透皮给药优点滚轮微针以不锈钢材料制成，数百微针/cm2贴片组成阵列，实现了多点注射给药的效果，又通过短暂破坏角质层，形成数百个孔道，药物依孔道进入真皮层，从而获得均匀疗效微针滚轮疗法是利用微针滚轮上许多微小的针头，刺激皮肤，在很短时间内微针可以做出个微细管道，令活性成分有效渗入皮肤，配以祛皱、美白、修复、祛疤痕等特效产品，从而达到减淡皱纹、治疗疤痕及妊娠纹、肌肤美白、减淡色斑、改善眼部皱纹、黑眼圈、收紧及提升面部皮肤组织等理想效果滚轮微针滚轮微针无痛 回复专家意见选择年龄60～80岁的老年患者作为实验对象滚轮 刁枢 师小伟张立超刘奇 【摘要】目的 观察滚轮微针预处理对利多卡因麻醉桡动脉穿刺镇痛效果的影响。方法 选取ASA分级Ⅰ或Ⅱ级择期手术患者90例，采用随机数字表法平均分为三组（n=30）。Ⅰ组利多卡因麻醉后桡动脉穿刺Ⅱ组Ⅲ组滚轮微针预处理利多卡因麻醉后桡动脉穿刺。采用疼痛视觉模拟评分（VAS）Wong-baker面部表情量表评估穿刺疼痛情况，统计穿刺一次成功率患者满意率，记录穿刺前后即刻生命体征变化，穿刺后48h内皮肤情况和其他不良反应发生情况。结果 三P0.05）Ⅰ组动脉穿刺后即刻患者生命体征较穿刺前升高（P 0.05），Ⅱ组和Ⅲ组VAS疼痛评分，Wong-baker面部表情量表疼痛等级明显，穿刺一次成功率于Ⅰ组（P 0.05），Ⅱ组于Ⅰ组和Ⅲ组（P 0.05）Ⅲ组（P0.05）三组均无严重不良反应发生。结论 滚轮微针预处理可增强利多卡因局部麻醉桡动脉穿刺镇痛效果。 【关键词】滚轮微针；预处理；利多卡因；麻醉；桡动脉穿刺Study of different length of microneedle roller pretreatment for lidocaine topical anesthesia analgesic effect of radial artery puncture DIAO-Shu, SHI Xiao-wei, ZHANG-Lichao，etal. Department of Anesthesiology，，China [Abstract]Objective:To evaluate the anagesia effects of different lengthicroneedle roller pretreatment for lidocaine topical anesthesia analgesic effect of radial artery puncture.Methods: Ninety elderly patients with ASA I or II undergoing selective operation were equally randomized into three groups with 30 cases each. GroupⅠreceived topical anesthesia of lidocaine before radial artery puncture. Group Ⅱ and Ⅲ received pretreatment of microneedle roller with length 500 μm and 750 μm then the same set of groupⅠ.VAS,Wong-baker scale,first puncture rate,patient satisfaction rate and side effects during 48 hours after operation were recorded and compared. Results: There was no significant difference of general information in three groups. Each index of vital signs were increased immediately after radial artery puncture in groupⅠ.VAS score and Wong-baker scale in group II and Ⅲ were decreased and first puncture rate higher than those in groupⅠ(P 0.05). Patients satisfaction rate in group II is higher than that in group I and group Ⅲ,