腰椎间盘突出症患者受累下肢骨骼肌的代谢与功能研究.docVIP

腰椎间盘突出症患者受累下肢骨骼肌代谢与功能的18氟代脱氧葡萄糖正电子发射/计算机辅助断层扫描成像氟代脱氧葡萄糖正电子发射/计算机辅助断层扫描成像最大标准化摄取值(SUVmax)日本骨科协会视觉类比疼痛评分0.01）。病例组△SUVmax与Oswestry功能障碍指数呈显著正相关性（R2=0.974,P0.01）；与JOA评分呈显著负相关（R2=-0.779, P0.01）。6例手术治疗术后6个月患侧受累肌群△SUVmax均较术前显著增加（P0.01）。结论 腰椎间盘突出症患者腰骶神经慢性卡压可致下肢受累骨骼肌葡萄糖代谢改变。该变化可通过18F-FDG PET/CT测定评估。18F-FDG PET/CT可作为腰椎间盘突出症患者下肢肌肉功能改变评估方法之一。 【关键词】 腰椎间盘突出症；下肢；肌肉；18氟代脱氧葡萄糖正电子发射/计算机辅助断层扫描成像Study of lower extremity muscles metabolism and function in lumbar disc herniation patients by 18F-fluorodeoxyglucose PET/CT imaging SHENG Haimin, LIU Yi, HE Wei, ZHANG Minjia, CAI Xiaoxi. Department of Orthopaedic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China 【Abstract】 Objective To compare and analyse the glucose metabolism of lower extremity musles in lumbar disc herniation(LDH) patients by 18F-fluorodeoxyglucose PET/CT imaging. Methods Twenty-two cases of single-level unilateral lumbar disc herniation patients were enrolled in this study. Their low extremities SUVmax were detected by 18F-FDG PET/CT, and the results were analysed and compared with contralateral muscles. And we analyzed the relationship between SUVmax and Osweestry disability index, Japanese Orthopaedic Association(JOA) score, visual analogue pain scale(VAPS). Results The involved muscles SUVmax were significantly lower than contralateral muscles(0.05±0.03 and 0.06±0.03, P0.01), the defferences between ipsilateral and contralateral SUVmax were significantly positively correlated with Oswestry disability index (R2=0.974, P0.01), and significantly negatively correlated with JOA score. Six cases were underwent surgery. The 6 months postoperative involved muscles SUVmaxs were significantly higher than preoperative（P0.01). Results The chronic compression of lumbosacral nerve in LDH patients could induce to involved low extremity muscles changes of glucose metabolism. These changes could be detected by 18-FDG PET/CT. 18F-FDG PET/CT would be one of methods to evaluate low extremity muscle function in LDH