左氧氟沙星治疗急性下呼吸道细菌感染的疗效观察.PDFVIP

3·66 · Chin J Nosocomiol Vol. 13 No. 4 2003 ·论 　著· 左氧氟沙星治疗急性下呼吸道 细菌感染的疗效观察 石彦明 , 宁 　康 , 周 　玲 , 于翠香 , 刘世青 ( 山东省千佛山医院 , 山东 济南 250014) 摘要 : 目的 　评价左氧氟沙星序贯疗法治疗急性下呼吸道细菌感染的疗效和安全性。方法 　对 38 例急性下呼 吸道细菌感染患者 ,采用左氧氟沙星 0. 3～0. 6 g/ d ,6 ～8 d 静脉滴注 ,继之以 0. 2 ,bid ,4～7 d ,po 。结果 　痊愈 11 例( ) ( ) ( ) 28. 95 % ,显效 24 例 60. 5 % ,有效率 92. 11 % ,细菌消除率 92. 86 % ,总疗程 10～15 d 平均 11. 6 d ,药物 ( ) 副作用较少 发生率 2. 63 % 。结论 　左氧氟沙星序贯疗法治疗急性下呼吸道常见细菌性感染有效、安全。 关键词 : 左氧氟沙星 ; 细菌感染 ; 下呼吸道感染 中图分类号: R563. 1 　　文献标识码 : A 　　文章编号 : (2003) Treatment of Acute Lower Respiratory Tract Bacterial Infection by Levofloxacin in Sequential Therapy SHI Yanming , N IN G Kang , ZHOU Ling , YU Cuixiang , L IU Shiqing ( ) Depart ment of Respi ratory Medicine , Qianf oshan Hospital , Jinan 250014 , China Abstract : OBJECTIVE To evaluate the efficacy and safety of levofloxacin in treatment of acute lower respiratory tract bacterial infection (AL RTBI) by sequential therap y. METHODS Thirty eight patients with AL RTBI were treated with levofloxacin iv drip in a regimen of 0. 30. 6 g/ d for 68d then with oral levofloxacin in dose of 0. 4 g/ d for 47d in se quence. RESULTS An effective rate of 92. 11 % and a bacterial eradication rate of 92. 86 % wereobtained with a tolera ble side effect of 2. 63 %. CONCL USIONS Levofloxacin in sequential therapy is an effective and safe agent for treatment