荷瘤小鼠静脉注射洛铂和顺铂后药物浓度的变化规律.pdfVIP

212 20 11 6 18 3 Ch in J C l in On col R ehab il, June 20 11, V ol 18, N o. 3 1 2 1 2 2 2 2 孙明霞 高献书 赵玉亮 秦尚彬 刘朝兴 张敏 李晓梅 ( 1. 北京大学第一医院肿瘤化疗科, 北京 100034; 2. 北京大学第一医院放射治疗科, 北京 100034) , 70 C57BL / 6 L ew is, 10m g / kg( ) , 0524244 87296 h ( ) , ICPM S , 5 1139h 355 83h, 0532L / ( h kg ) 0192 L / ( h kg) ] ; ( 279 035) g / g( 478 111) g / g ] , , 4 h 099 02 1 g / g 339 055 g / g, 96 h , 023 005 g / g 14 1 071 g / g , R sq 094 8 0837 , , 4 h , 96 h , ; ; ; ; ; ; ; ; R 730. 53; R 7336 A ( 20 11) The concentration changes of lobaplatin and cisplatin injected intravenously in m ice bearing lew is lung carcinom a S UN M ing x ia, GA O X ianshu, ZH A O Yuliang, et al ( D epartm ent o f R ad iation Onco logy, D epartm ent o f Onco logy Chemopherapy, Pek ing U niversity F irstH ospi ta,l Be ij ing 1000 34, Ch ina) Abstract Objective To prov ide expermi ental data for rad iosensitization by determ in ing the con centration change o f lobaplatin and cisplatin in plasm a, tumo r and k idney of m ice bear ing L ew is L ung Carci nom a. M ethods A fter adm in ister ing a 10m g / kg sing le intrav enou s bo lu s in jection o f e ithe r lobap la tin or cisplatin, b lood and tissues( tumo r and k idney) o fm ice w ere co llected at the indicated tmi e pionts( 05, 2, 4, 24, 4 8, 72, and 96 h) . T he platinum levels w ere determ ined by inductive ly coup led p lasm am ass spectrom e try. R esults T he plasm a concentrationtmi e curves of both lobap latin and cisp latin w ere fitted to a three compartment model w ith the ha lf life o f 51139 h and 355 83 h, respectively. Loba