单纯性肥胖男童血清瘦素及胰岛素性激素检测结果研究.doc

单纯性肥胖男童血清瘦素及胰岛素性激素检测结果研究【摘要】 目的 研究单纯性肥胖男性儿童血清瘦素、胰岛素及性激素水平之间的关系,为青少年肥胖的干预提供依据。方法 以10～15岁单纯性肥胖和正常对照儿童各22名为研究对象,用放射免疫法测定血清中的瘦素、胰岛素和性激素水平。结果 单纯性肥胖男生血清瘦素、胰岛素和雌二醇水平显著高于正常男童(P值均0.01),睾酮水平则明显低于正常男童(P0.01)。 血清瘦素水平与胰岛素、睾酮、雌二醇水平均有显著相关(P值均0.01)。结论 高水平瘦素可能是单纯性肥胖重要的生物学标志之一。单纯性肥胖男童存在性激素代谢紊乱、性发育落后,瘦素可能影响男性肥胖儿童的性发育。 【关键词】 肥胖症;瘦素;性腺甾类激素;胰岛素;血清学试验;儿童 【中图分类号】 R 179 R 339.3+5 【文献标识码】 A 【文章编号】 1000-9817(2009)08-0728-02 Detection and Analysis of Leptin, Insulin and Sexual Hormone in Serum of Simple Obesity Boys/JIA Li-xia*,ZHANG Hong-yan, LIU Ji-xing et al. * Medical College of Hebei University of Engineering, Handan(056002), Hebei Province, China 【Abstract】 Objective To study the level of leptin, insulin and sexual hormone in serum of simple obesity boys and to explore their mutual relationship. Methods The objects were 22 simple obesity boys and 22 normal boys(aged 10-15). The level of leptin, insulin and sexual hormone in serum were determined by radioimmunoassay. Results The level of leptin, insulin and dihydrofolliculin in serum of simple obesity boys were higher than those of normal boys(P0.01). The level of testosterone in serum of simple obesity boys were lower than those of normal boys(P0.01).Serum leptin was significantly correlated with insulin, testosterone and dihydrofolliculin.Conclusion High level of leptin is one of the biology mark to simple obesity. There are sex hormone metabolic disorder and lagged sex development for simple obesity boys. Leptin can affect sex development for obesity boys. 【Key words】 Obesity;Leptin;Gonadal steroid hormones;Insulin;Serologic tests;Child 近年来,随着经济的发展和饮食结构的调整,肥胖及与肥胖相关的疾病日益受到人们的关注,儿童单纯性肥胖的发生率也呈日益增加的趋势[1]。由于儿童处于一个特殊的生长发育阶段,肥胖不但会对儿童的身体健康造成严重威胁,而且可能影响儿童性发育;但也有相反的研究结果。为明确单纯性肥胖是否对男童的性发育存在影响,笔者通过对单纯性肥胖儿童血清瘦素、胰岛素、睾酮、雌二醇水平的检测,对其相关关系及对儿童性发育的影响进行初步分析。 1 对象与方法 1 对象 以中国学生7～22岁身高标准体重值[2]为标准,凡实际体重超过标准体重20%即为肥胖,实际体重在标准体重±10%之内均为正常。经体检、询问病史、排除内分泌等继发性肥胖后,选取22名单纯性肥胖男性儿童为研究对象,年龄10～15岁。按1∶1配对的方法选取同年龄(出生年月相差3个月以内)、体重正常的儿童22名作为对照组。 1.