阿托伐他汀对高脂血症患者左心室心肌功能的影响.docVIP

阿托伐他汀对高脂血症患者左心室心肌功能的影响 肖秀娟1张岩1 魏海燕1 李海朋1 庞远1 谢艳凤1 （1. 唐山市协和医院超声科，河北 唐山 063004）( [摘要]目的：探讨无冠心病证据高脂血症患者左心室心肌功能的影响。方法：选取2例无冠心病证据的高脂血症患者18例性别及年龄相匹配的健康者为对照组，均接受传统二维彩色多普勒超声心动图、脉冲波组织多普勒成像及背向散射积分检查。结果：与对照组比较，研究组无论传统二维彩色多普勒超声心动图或是脉冲波组织多普勒成像检查P0.01）P0.01）E/A和Ea/Aa比值明显降低（P0.01），且Tei指数显著增加(P0.01)；背向散射积分参数周期变指数明显（P0.0）Tei指数）周期变指数。结论：高脂血症左心室心肌[关键词] 高脂血症，彩色多普勒心肌成像，背向散射积分，心肌功能 TXIAO Xiujuan1, ZHANG Yan1, LI Haipeng1, PANGYuan1, XIE Yanfeng1 (1. Department of Echocardiography, Tangshan Union Hospital, Tangshan, 063004, China) Abstract Objective: To explore the effects of atorvastatin on left ventricular myocardial function in hypercholesterolemia patients without coronary heart disease. Methods: 21 patients with hypercholesterolemia and without evidence of coronary heart disease and 18 sex- and age-matched healthy volunteers were studied. All subjects were submitted to conventional 2D color-Doppler echocardiography (2D-CDE), pulsed wave tissue Doppler imaging (PWTDI) for the analysis of diastolic function, and to integrated backscatter (IBS) for the evaluation of intrinsic contractility and tissue characterization. Echocardiographic evaluation was repeated after six months of treatment with atorvastatin (20mg/day) in 21 hypercholesterolemia patients. Results: E peak velocity and Ea were reduced（P0.05）, A peak velocity were remarkly increased（P0 E/A ratio and Ea/Aa ratio were significantly lower (P0.01). Tei index were remarkly increased (P0.01) in hypercholesterolemia patients, regardless of 2D-CDE and PWTDI examinations. Cyclic Variation index in integrated backscatter were significantly reduced (P0.05). Compared to pre-treatment, Tei index were remarkly decreased (P0.01) and Cyclic Variation index in integrated backscatter were significantly increased (P0.01) in hypercholesterolemia patients after six months of atorvastatin treatment. Conclusions: The present study suggests that long-term treatment with atorvastatin can improve the impaired left ventricular myocardial function