expression of thymidine phosphorylase in lymph nodes involved with mycosis fungoides and sézary syndrome胸苷磷酸化酶的表达在淋巴结和蕈样sezary综合症.pdfVIP

Hindawi Publishing Corporation Advances in Hematology Volume 2011, Article ID 875135, 6 pages doi:10.1155/2011/875135 Research Article Expression of Thymidine Phosphorylase in Lymph Nodes ´ Involved with Mycosis Fungoides and Sezary Syndrome Xingcao Nie,1 Rekha Bhat,1 Essel Dulaimi Al-Saleem,1 Eric C. Vonderheid,2 and J. Steve Hou1 1 Department of Pathology, Drexel University College of Medicine, 245 N. 15th Street, Mail Stop 435, Philadelphia, PA 19102, USA 2 Johns Hopkins Medical Institutes, Baltimore, MD, USA Correspondence should be addressed to J. Steve Hou, j.hou@ Received 9 June 2011; Revised 1 September 2011; Accepted 2 September 2011 Academic Editor: Michael L. Grossbard Copyright © 2011 Xingcao Nie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Thymidine phosphorylase may be overexpressed in both neoplastic cells and tumor stromal cells in a variety of malignancies. Our study explores thymidine phosphorylase expression in lymph nodes (LNs) from patients with mycosis fungoides (MF) or ´ Sezary syndrome (SS). In MF/SS, the LNs may have a pathologic diagnosis of either dermatopathic lymphadenopathy (LN-DL) or involvement by MF/SS (LN-MF). We performed immunohistochemical staining on MF/SS lymph nodes using antibodies to thymidine phosphorylase, CD68, CD21, CD3, and CD4. In both LN-DL and benign nodes, thymidine phosphorylase staining was noted only in macrophages, dendritic cells, and endothelial cells. In LN-MF, thymidine phosphorylase expression was also noted in subsets of intermediate to large neop