fibronectin binding is required for acquisition of mesenchymalendothelial differentiation potential in human circulating monocytes纤连蛋白绑定需要收购mesenchymalendothelial人类循环单核细胞分化潜能.pdfVIP

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fibronectin binding is required for acquisition of mesenchymalendothelial differentiation potential in human circulating monocytes纤连蛋白绑定需要收购mesenchymalendothelial人类循环单核细胞分化潜能.pdf

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fibronectin binding is required for acquisition of mesenchymalendothelial differentiation potential in human circulating monocytes纤连蛋白绑定需要收购mesenchymalendothelial人类循环单核细胞分化潜能

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 820827, 9 pages doi:10.1155/2012/820827 Research Article Fibronectin Binding Is Required for Acquisition of Mesenchymal/Endothelial Differentiation Potential in Human Circulating Monocytes Noriyuki Seta,1 Yuka Okazaki,1 Keisuke Izumi,1 Hiroshi Miyazaki,2 Takashi Kato,1, 3 and Masataka Kuwana1 1 Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan 2 Innovative Drug Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., 3 Miyahara, Takasaki, Gunma 370-1295, Japan 3 Department of Biology, School of Education, Waseda University, 2-2 Wakamatsu, Shinjuku-ku, Tokyo 162-8480, Japan Correspondence should be addressed to Masataka Kuwana, kuwanam@z5.keio.jp Received 4 July 2012; Accepted 24 September 2012 Academic Editor: Jacek Tabarkiewicz Copyright © 2012 Noriyuki Seta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We previously reported monocyte-derived multipotential cells (MOMCs), which include progenitors capable of diﬀerentiating into a variety of mesenchymal cells and endothelial cells. In vitro generation of MOMCs from circulating CD14+ monocytes requires their binding to extracellular matrix (ECM) protein and exposure to soluble factor(s) derived from circulating CD14− cells. Here, we investigated the molecular factors involved in MOMC generation by examining the binding of monocytes to ECM proteins. We found that MOMCs were obtained on the ﬁbronectin, but not on type I col