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Hindawi Publishing Corporation Advances in Virology Volume 2011, Article ID 713769, 11 pages doi:10.1155/2011/713769 Research Article Bacterial Toxin Fusion Proteins Elicit Mucosal Immunity against a Foot-and-Mouth Disease Virus Antigen When Administered Intranasally to Guinea Pigs Sreerupa Challa,1, 2, 3 Steven M. Szczepanek,2, 4 Debra Rood,2, 4 Roger W. Barrette,1, 2, 5 and Lawrence K. Silbart2, 4 1 Department of Animal Science, University of Connecticut, Storrs, CT 06269, USA 2 Center of Excellence for Vaccine Research, University of Connecticut, Storrs, CT 06269-2191, USA 3 Department of Biomedical Sciences, Division of Infectious Diseases, Tufts Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA 4 Department of Allied Health Sciences, University of Connecticut, Storrs, CT 06269, USA 5 Plum Island Animal Disease Center, USDA-APHIS/VS/FADDL, Greenport, NY 11944, USA Correspondence should be addressed to Lawrence K. Silbart, lawrence.silbart@ Received 15 April 2011; Revised 7 June 2011; Accepted 21 June 2011 Academic Editor: George K. Lewis Copyright © 2011 Sreerupa Challa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Peptides corresponding to the foot-and-mouth disease virus VP1 G-H loop are capable of inducing neutralizing antibodies in some species but are considered relatively poor immunogens, especially at mucosal surfaces. However, intranasal administration of antigens along with the appropriate delivery vehicle/adjuvant has been shown to induce mucosal immune responses, and bacterial enterotoxins have long been known to be effective i