bone blood flow is influenced by muscle contractions骨骼血液流动是由肌肉收缩的影响.pdfVIP

J. Biomedical Science and Engineering, 2011, 4, 490-496 JBiSE doi:10.4236/jbise.2011.47062 Published Online July 2011 (http://www.SciRP.org/journal/jbise/). Bone blood flow is influenced by muscle contractions Jan Erik Näslund1 2 1 3 1 , Sofie Näslund , Erik Lundeberg , Lars-Göran Lindberg , Iréne Lund 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 2Gävle Hospital, Gävle, Sweden; 3Department of Biomedical Engineering, Linköping University, Linköping, Sweden. Email: Jan.E.Naslund@ki.se; s_n_a_s@; erik_lundeberg@; larli@imt.liu.se; Irene.Lund@ki.se Received 18 April 2011; revised 11 May 2011; accepted 27 May, 2011. ABSTRACT and are remodeled in response to mechanical loading. It is however not totally agreed on how forces acting on Forces acting on the skeleton could be divided into bone cells influence bone morphology (mechanotrans- those originating from gravitational loading and those duction), but the importance of solute transport for cel- originating from muscle loading. Flat bones in a lular mechanotransduction [1] and cellular excitation due non-weight-baring segment of the skeleton probably to interstitial fluid flow (IFF) have been implicated [2]. experience forces mostly generated by muscle con- The contribution of strain in terms of magnitude, rate, tractions. One purpose of muscle contractions is to cycles and unusual distribution, is still a matt