carbonic anhydrase vii–a potential prognostic marker in gliomas碳酸酐酶第七潜在神经胶质瘤的预后指标.pdfVIP

Vol.3, No.1, 6-12 (2011) Health doi:10.4236/health.2011.31002 Carbonic anhydrase VII–a potential prognostic marker in gliomas 1,2 3 1 3 Fatemeh Bootorabi , Joonas Haapasalo , Elona Smith , Hannu Haapasalo , Seppo Parkkila1,2 1Institute of Medical Technology and School of Medicine, University of Tampere, Tampere, Finland 2Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland 3Department of Pathology, Centre for laboratory Medicine, Tampere University Hospital, Tampere, Finland; *Corresponding Author: seppo.parkkila@uta.fi Received 7 December 2010; revised 20 December 2010; accepted 26 December 2010 ABSTRACT Oligodendroglioma; pH Carbonic anhydrase VII (CA VII) is a cytosolic 1. INTRODUCTION enzyme expressed in several organs, including the human brain, but it has not been investi- Carbonic Anhydrase (CAs) form a family of ubiquit- gated earlier in any tumors. We designed the ous zinc containing metalloenzymes that are able to cat- present study to evaluate CA VII expression in a alyze the reversible hydration of carbon dioxide accord- cohort of human diffuse astrocytomas, mixed ing to the following reaction: CO + H O ⇔HCO − + 2 2 3 oligoastrocytomas and oligodendrogliomas. CA H+. The CAs show different distribution in a variety of VII immunostaining was correlated to clinico- tissues where the