cancer cell invasion of brain tissue guided by a prepattern癌细胞的入侵脑组织prepattern引导.pdfVIP

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cancer cell invasion of brain tissue guided by a prepattern癌细胞的入侵脑组织prepattern引导.pdf

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cancer cell invasion of brain tissue guided by a prepattern癌细胞的入侵脑组织prepattern引导

Journal of Theoretical Medicine, Vol. 6, No. 1, March 2005, 21–31 Cancer cell invasion of brain tissue: guided by a prepattern? MICHAEL WURZEL†, CARLO SCHALLER‡, MATTHIAS SIMON‡ and ANDREAS DEUTSCH†* †Center for High Performance Computing, Dresden University of Technology D-01062, Dresden, Germany ‡Department of Neurosurgery, Medical Center, University of Bonn, Bonn, Germany (Received 2 August 2004; in ﬁnal form 29 November 2004) The malignant brain tumour Glioblastoma multiforme (GBM) displays a highly invasive behaviour. Spreading of the malignant cells appears to be guided by the white matter ﬁbre tracts within the brain. In order to understand the global growth process we introduce a lattice-gas cellular automaton model which describes the local interaction between individual malignant cells and their neighbourhood. We consider interactions between cells (brain cells and tumour cells) and between malignant cells and the ﬁbre tracts in the brain, which are considered as a prepattern. The prepattern implies persistent individual cell motion along the ﬁbre structure. Simulations with the model show that only the inclusion of the prepattern results in invading tumour and growing tumour islets in front of the expanding tumour bulk (i.e. the growth pattern observed in clinical practice). Our results imply that the inﬁltrative growth of GBMs is, in part, determined by the physical structure of the surrounding brain rather than by intrinsic properties of the tumour cells. Keywords: Glioblastoma; White matter; Fibre tracts; Lattice-gas cellular automation; Expansive