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cardiovascular prevention of cognitive decline心血管预防认知能力下降
SAGE-Hindawi Access to Research
Cardiology Research and Practice
Volume 2011, Article ID 250970, 7 pages
doi:10.4061/2011/250970
Review Article
Cardiovascular Prevention of Cognitive Decline
1 ` 2 3
Jean-Jacques Monsuez, Aude Gesquiere-Dando, and Sofia Rivera
1AP-HP, Hˆopital Ren´e Muret, Hˆopitaux Universitaires de Paris Seine-Saint-Denis, Policlinique M´edicale,
Avenue du Docteur Schaeff ner, 93270 Sevran, France
2 Service de Neurologie, Hˆopital de la Timone, 13385 Marseille, France
3 Service d’Oncologie-Radioth´erapie, AP-HP Hˆopital Saint-Louis, 75475 Paris, France
Correspondence should be addressed to Jean-Jacques Monsuez, jean-jacques.monsuez@rmb.aphp.fr
Received 8 September 2010; Accepted 23 December 2010
Academic Editor: Christina Chrysohoou
Copyright © 2011 Jean-Jacques Monsuez et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Midlife cardiovascular risk factors, including diabetes, hypertension, dyslipemia, and an unhealthy lifestyle, have been linked
to subsequent incidence, delay of onset, and progression rate of Alzheimer disease and vascular dementia. Conversely, optimal
treatment of cardiovascular risk factors prevents and slows down age-related cognitive disorders. The impact of antihypertensive
therapy on cognitive outcome in patients with hypertension was assessed in large trials which demonstrated a reduction in
progression of MRI white matter hyperintensities, in cognitive decline and in incidence of dementia.
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