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cardiovascular disease, single nucleotide polymorphisms; and the renin angiotensin system is there a microrna connection心血管疾病、单核苷酸多态性;.pdf

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cardiovascular disease, single nucleotide polymorphisms; and the renin angiotensin system is there a microrna connection心血管疾病、单核苷酸多态性;

SAGE-Hindawi Access to Research International Journal of Hypertension Volume 2010, Article ID 281692, 13 pages doi:10.4061/2010/281692 Review Article Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System: Is There a MicroRNA Connection? Terry S. Elton,1, 2, 3 Sarah E. Sansom,1 and Mickey M. Martin1 1 Davis Heart and Lung Research Institute, The Ohio State University, DHLRI 515, Columbus, OH 43210, USA 2 Division of Pharmacology, College of Pharmacy, The Ohio State University, OH 43210, USA 3 Department of Medicine, College of Medicine, Division of Cardiology, The Ohio State University, OH 43210, USA Correspondence should be addressed to Terry S. Elton, terry.elton@ Received 4 May 2010; Accepted 25 June 2010 Academic Editor: Stephen B. Harrap Copyright © 2010 Terry S. Elton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Essential hypertension is a complex disorder, caused by the interplay between many genetic variants, gene-gene interactions, and environmental factors. Given that the renin-angiotensin system (RAS) plays an important role in blood pressure (BP) control, cardiovascular regulation, and cardiovascular remodeling, special attention has been devoted to the investigation of single- nucleotide polymorphisms (SNP) harbored in RAS genes that may be associated with hypertension and cardiovascular disease. MicroRNAs (miRNAs) are a family of small, ∼21-nucleotide long, and nonprotein-coding RNAs that recognize target mRNAs through partial complementary elements i