cardiac conduction safety during coadministration of artemether-lumefantrine and lopinavirritonavir in hiv-infected ugandan adults心脏传导安全蒿甲醚在共同服用苯芴醇,在感染艾滋病毒的乌干达lopinavirritonavir成年人.pdfVIP

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cardiac conduction safety during coadministration of artemether-lumefantrine and lopinavirritonavir in hiv-infected ugandan adults心脏传导安全蒿甲醚在共同服用苯芴醇,在感染艾滋病毒的乌干达lopinavirritonavir成年人.pdf

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cardiac conduction safety during coadministration of artemether-lumefantrine and lopinavirritonavir in hiv-infected ugandan adults心脏传导安全蒿甲醚在共同服用苯芴醇,在感染艾滋病毒的乌干达lopinavirritonavir成年人

Hindawi Publishing Corporation Chemotherapy Research and Practice Volume 2011, Article ID 393976, 4 pages doi:10.1155/2011/393976 Research Article Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and Lopinavir/Ritonavir in HIV-Infected Ugandan Adults Pauline Byakika-Kibwika,1, 2, 3 Mohammed Lamorde,1, 2 Peter Lwabi,4 Wilson B. Nyakoojo,4 Violet Okaba-Kayom,1 Harriet Mayanja-Kizza,1, 3 Marta Bofﬁto,5 Elly Katabira,1, 3 David Back,6 Saye Khoo,6 and Concepta Merry1, 2, 3 1 Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda 2 Trinity College, Dublin 2, Ireland 3 Infectious Diseases Network for Treatment and Research in Africa (INTERACT), P.O. Box 7062, Kampala, Uganda 4 Uganda Heart Institute, Mulago Hospital, P.O Box 7051, Kampala, Uganda 5 St. Stephen’s AIDS Trust, London SW10 9TR, UK 6 University of Liverpool, Liverpool L69 3BX, UK Correspondence should be addressed to Pauline Byakika-Kibwika, pbyakika@ Received 31 August 2010; Revised 26 November 2010; Accepted 14 February 2011 Academic Editor: Kazuo Tamura Copyright © 2011 Pauline Byakika-Kibwika et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. We aimed to assess cardiac conduction safety of coadministration of the CYP3A4 inhibitor lopinavir/ritonavir (LPV/r) and the CYP3A4 substrate artemether-lumefantrine (AL) in HIV-positive Ugandans. Methods. Open-label safety study of HIV- positive adults administered single-dose AL (80/400 mg) alone or with LPV/r (400/100 mg). Cardiac function was monitored using continuous electrocard